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Spectrum of very early breast cancer in a setting without organised screening

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dc.contributor.authorBhoo-Pathy, Nen_US
dc.contributor.authorSubramaniam, Sen_US
dc.contributor.authorTaib, NAen_US
dc.contributor.authorHartman, Men_US
dc.contributor.authorAlias, Zen_US
dc.contributor.authorTan, GHen_US
dc.contributor.authorIbrahim, RIen_US
dc.contributor.authorYip, CHen_US
dc.contributor.authorVerkooijen, HMen_US
dc.date.accessioned2024-05-29T03:25:26Z
dc.date.available2024-05-29T03:25:26Z
dc.date.issued2014
dc.descriptionBritish Journal of Cancer (2014), 1–8en_US
dc.description.abstractBackground: Within a setting without organised breast cancer screening, the characteristics and survival of very early breast cancer were determined. Methods: All 4930 women diagnosed with breast cancer in University Malaya Medical Center, Malaysia from 1993 to 2011 were included. Factors associated with very early presentation (stage I) at diagnosis were identified. Tumour characteristics, management patterns, and survival of very early breast cancer were described, and where appropriate, compared with other settings. Results: Proportion of women presenting with stage I breast cancer significantly increased from 15.2% to 25.2% over two decades. Factors associated with very early presentation were Chinese ethnicity, positive family history of breast cancer, and recent period of diagnosis. Within stage I breast cancers, median tumour size at presentation was 1.5 cm. A majority of stage I breast cancer patients received mastectomy, which was associated with older age, Chinese ethnicity, postmenopausal status, and larger tumours. Chemotherapy was administered in 36% of patients. Five-year age-adjusted relative survival for women with stage I breast cancer was 99.1% (95% CI: 97.6-99.6%). Conclusions: The proportion of women presenting with very early breast cancer in this setting without organised screening is increasing. These women seem to survive just as well as their counterparts from affluent settings.en_US
dc.identifier.doi10.1038/bjc.2014.183
dc.identifier.epage2194
dc.identifier.issn0007-0920
dc.identifier.issue9
dc.identifier.scopusWOS:000335562800004
dc.identifier.spage2187
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84899920195&doi=10.1038%2fbjc.2014.183&partnerID=40&md5=ddb3d2ce5e54e7669e895f4a8a30505e
dc.identifier.urihttps://www.nature.com/articles/bjc2014183.pdf
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/11962
dc.identifier.volume110
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofBritish Journal Of Canceren_US
dc.sourceWeb Of Science (ISI)
dc.subjectearly breast canceren_US
dc.subjectstage Ien_US
dc.subjectAsianen_US
dc.subjectmammographyen_US
dc.subjectscreeningen_US
dc.subjectmastectomyen_US
dc.titleSpectrum of very early breast cancer in a setting without organised screeningen_US
dc.typeArticleen_US
dspace.entity.typePublication

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