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Associations between primary hypertension and genes in the renin angiotensin system: A prospective two-center study in university kebangsaan malaysia medical center and international medical university cardiology clinic

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dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.affiliationsNational Heart Institute
dc.contributor.affiliationsCyberjaya University College of Medical Science
dc.contributor.affiliationsUniversiti Kebangsaan Malaysia (UKM)
dc.contributor.authorJuliana N.en_US
dc.contributor.authorYahaya S.en_US
dc.contributor.authorMohamed A.L.en_US
dc.contributor.authorHarun R.en_US
dc.date.accessioned2024-05-28T08:25:03Z
dc.date.available2024-05-28T08:25:03Z
dc.date.issued2010
dc.description.abstractThis study targeted two candidate genes from the best known regulator of blood pressure; the rennin angiotensin system; the ACE gene lID polymorphism and the angiotensinogen M235T polymorphism. The study aimed to determine the genotypes trend between two different populations; the primary hypertensive patients, and the normal populations. 126 subjects were involved in this study (86 primary hypertensive patients and 40 normal individuals). All demographic factors were considered and analyzed. Insertion1deletion polymorphisms of the ACE gene were determined by an assay based on the polymerase chain reaction (PCR). Polymorphism analysis using PCR-RFLP procedure was used to identify the missense mutation M235T of the AGT gene. All significant data was collected using standardized case report form. The association of the different genotypes and the subjects' condition was analyzed using the chi squared and odds ratio analyses. In the pooled analysis of both groups, it was shown that the polymorphisms in these genes were significantly associated with the incidence of primary hypertension, p>O.O5. Results also showed that the D allele of the ACE gene may be associated with increased risk of primary hypertension (p>O.O5, OR: 3.0 [CI: 1.25 - 5.35]). The angiotensinogen M235T polymorphism also showed a significant result; the T allele is associated with increased risk of primary hypertension (p>O.O5, OR: 2.56[C.I: 1.55 -5.28]). This knowledge of the candidate genes of rennin angiotensin system has rendered it possible to show that gene polymorphism in symphony leads to the individual risk of primary hypertension.
dc.description.natureFinalen_US
dc.identifier.epage24
dc.identifier.issn16758544
dc.identifier.issue2
dc.identifier.scopus2-s2.0-78650646489
dc.identifier.spage19
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-78650646489&partnerID=40&md5=858a931f61ce9b5a9549ed056ea1a072
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/8602
dc.identifier.volume6
dc.languageEnglish
dc.language.isoen_US
dc.relation.ispartofMalaysian Journal of Medicine and Health Sciences
dc.sourceScopus
dc.subjectACEen_US
dc.subjectHypertensionen_US
dc.subjectM235Ten_US
dc.subjectRenninen_US
dc.titleAssociations between primary hypertension and genes in the renin angiotensin system: A prospective two-center study in university kebangsaan malaysia medical center and international medical university cardiology clinic
dc.typeArticleen_US
dspace.entity.typePublication

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