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Modeling and optimization of lipase-catalyzed synthesis of dilauryl adipate ester by response surface methodology

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dc.contributor.authorRahman, MBAen_US
dc.contributor.authorChaibakhsh, Nen_US
dc.contributor.authorBasri, Men_US
dc.contributor.authorRahman, RNZRAen_US
dc.contributor.authorSalleh, ABen_US
dc.contributor.authorRadzi, SMen_US
dc.date.accessioned2024-05-29T02:51:22Z
dc.date.available2024-05-29T02:51:22Z
dc.date.issued2008
dc.description.abstractBACKGROUND: Adipate esters are used as low-temperature and low-viscosity plasticizers for polyvinyl chloride and its copolymers. In this work, optimization of lipase-catalyzed production of dilauryl adipate was carried out using response surface methodology (RSM) based on a four-factor-five-level central composite rotatable design (CCRD). Immobilized lipase from Candida antarctica (Novozym 435) was used as catalyst in this reaction. Various reaction parameters affecting the synthesis of adipate ester, including alcohol/acid molar ratio, amount of enzyme, temperature and reaction time, were investigated. RESULTS: Statistical analysis showed that the amount of enzyme was less significant than the other three factors. The optimal conditions for the enzymatic reaction were obtained at 5.7:1 substrate molar ratio using 0.18g of enzyme at 53.1 degrees C for 282.2 min. Under these conditions the esterification percentage was 96.0%. CONCLUSIONS: The results demonstrated that response surface methodology can be applied effectively to optimize the lipase-catalyzed synthesis of adipate ester. The optimum conditions can obtained be used to scale up the process. (C) 2008 Society of Chemical Industry
dc.identifier.doi10.1002/jctb.1960
dc.identifier.epage1540
dc.identifier.issn0268-2575
dc.identifier.issue11
dc.identifier.scopusWOS:000260360300013
dc.identifier.spage1534
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/11188
dc.identifier.volume83
dc.languageEnglish
dc.language.isoen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Chemical Technology And Biotechnology
dc.sourceWeb Of Science (ISI)
dc.subjectlipaseen_US
dc.subjectesterificationen_US
dc.subjectadipate esteren_US
dc.subjectresponse surface methodologyen_US
dc.subjectcentral composite rotatable designen_US
dc.titleModeling and optimization of lipase-catalyzed synthesis of dilauryl adipate ester by response surface methodology
dc.typeArticleen_US
dspace.entity.typePublication

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