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Human Papillomavirus 16 E2 as an Apoptosis-Inducing Protein for Cancer Treatment: A Systematic Review

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dc.contributor.authorDinah Farhanah Jamalen_US
dc.contributor.authorQuratul Ain Rozaimeeen_US
dc.contributor.authorNadila Haryani Osmanen_US
dc.contributor.authorAtikah Mohd Sukoren_US
dc.contributor.authorMarjanu Hikmah Eliasen_US
dc.contributor.authorNor Aripin Shamaanen_US
dc.contributor.authorSrijit Dasen_US
dc.contributor.authorNazefah Abdul Hamiden_US
dc.date.accessioned2024-05-28T04:30:40Z
dc.date.available2024-05-28T04:30:40Z
dc.date.issued2022
dc.date.submitted2022-10-25
dc.descriptionInt. J. Mol. Sci. 2022, 23(20),en_US
dc.description.abstractHuman papillomavirus type 16 (HPV-16) is a well-known etiological factor for cervical and oropharyngeal cancers. The E2 protein, the product of an early-transcribed gene in HPV–16, is postulated to cause the death of cancerous cells via p53-dependent and p53-independent pathways. The main aim of the present systematic review was to study the HPV 16-E2 protein as an apoptosis-inducer agent. A thorough search of MEDLINE/PubMed, Science Direct, Scopus, and EBSCOhost databases was conducted for relevant studies on HPV AND apoptosis OR cell death where HPV 16-E2 was involved. The search identified 967 publications. Eleven records dated from 1 January 1997 to 16 February 2022 were found to meet the inclusion criteria and were eligible for data extraction and inclusion. All studies concluded that HPV 16-E2 was able to induce cell death in transfected cells. E2 proteins from the high-risk HPV–16 were able to induce apoptosis through different apoptotic pathways depending on the location of the expressed gene. However, the mechanism was still unclear, and further studies are warranted.en_US
dc.identifier.citationJamal, D.F.; Rozaimee, Q.A.; Osman, N.H.; Mohd Sukor, A.; Elias, M.H.; Shamaan, N.A.; Das, S.; Abdul Hamid, N. Human Papillomavirus 16 E2 as an Apoptosis-Inducing Protein for Cancer Treatment: A Systematic Review. Int. J. Mol. Sci. 2022, 23, 12554. https://doi.org/10.3390/ijms232012554en_US
dc.identifier.doi10.3390/ijms232012554
dc.identifier.epage17
dc.identifier.issn1422-0067
dc.identifier.issue20
dc.identifier.other444-24
dc.identifier.spage1
dc.identifier.urihttps://www.mdpi.com/1422-0067/23/20/12554
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/5785
dc.identifier.volume23
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofInternational Journal of Molecular Sciencesen_US
dc.subjectapoptosis; cell death; E2 protein; human papillomavirus; HPV 16en_US
dc.titleHuman Papillomavirus 16 E2 as an Apoptosis-Inducing Protein for Cancer Treatment: A Systematic Reviewen_US
dc.typeArticleen_US
dspace.entity.typePublication

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