Publication: Multiple Myeloma: Challenges Encountered and Future Options for Better Treatment
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI
Abstract
Multiple myeloma (MM) is a malignant hematological disease. The disease is characterized by the clonal proliferation of malignant plasma cells in the bone marrow. MM accounts for 1.3% of all malignancies and has been increasing in incidence all over the world. Various genetic abnormalities, mutations, and translocation, including epigenetic modifications, are known to contribute to the disease’s pathophysiology. The prognosis is good if detected early, or else the outcome is very bad if distant metastasis has already occurred. Conventional treatment with drugs poses a challenge when there is drug resistance. In the present review, we discuss multiple myeloma and its treatment, drug resistance, the molecular basis of epigenetic regulation, the role of natural products in epigenetic regulators, diet, physical activity, addiction, and environmental pollutants, which may be beneficial for clinicians and researchers.
Description
Volume 23 Issue 3
Keywords
multiple myeloma; management; drug resistance; epigenetic; modifications
Citation
Das S, Juliana N, Yazit NAA, Azmani S, Abu IF. Multiple Myeloma: Challenges Encountered and Future Options for Better Treatment. International Journal of Molecular Sciences. 2022; 23(3):1649. https://doi.org/10.3390/ijms23031649
URI
https://www.mdpi.com/1422-0067/23/3/1649
https://www.scopus.com/record/display.uri?eid=2-s2.0-85123709090&origin=resultslist&sort=plf-f&src=s&sid=3f1868111a303d5a05d758a34d75371e&sot=b&sdt=b&s=TITLE-ABS-KEY%28Multiple+Myeloma+Challenges+Encountered+and+Future+Options+for+Better+Treatment%29&sl=151&sessionSearchId=3f1868111a303d5a05d758a34d75371e
https://oarep.usim.edu.my/handle/123456789/10709
https://www.scopus.com/record/display.uri?eid=2-s2.0-85123709090&origin=resultslist&sort=plf-f&src=s&sid=3f1868111a303d5a05d758a34d75371e&sot=b&sdt=b&s=TITLE-ABS-KEY%28Multiple+Myeloma+Challenges+Encountered+and+Future+Options+for+Better+Treatment%29&sl=151&sessionSearchId=3f1868111a303d5a05d758a34d75371e
https://oarep.usim.edu.my/handle/123456789/10709