Publication:
Immature reticulocyte fraction is an early predictor of bone marrow recovery post chemotherapy in patients with acute leukemia

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dc.citedby2
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.affiliationsUniversitI Kebangsaan Malaysia (UKM) Medical Center
dc.contributor.authorRaja-Sabudin A.R.-Z.en_US
dc.contributor.authorOthman A.en_US
dc.contributor.authorAhmed-Mohamed K.-A.E.en_US
dc.contributor.authorIthnin A.en_US
dc.contributor.authorAlauddin H.en_US
dc.contributor.authorAlias H.en_US
dc.contributor.authorAbdul-Latif Z.en_US
dc.contributor.authorDas S.en_US
dc.contributor.authorAbdul-Wahid F.S.en_US
dc.contributor.authorHussin N.H.en_US
dc.date.accessioned2024-05-29T02:00:49Z
dc.date.available2024-05-29T02:00:49Z
dc.date.issued2014
dc.description.abstractObjectives: To establish the benefits of immature reticulocyte fraction (IRF) measurement using an automated hematology cells analyzer over absolute neutrophil count (ANC) in predicting bone marrow recovery post induction chemotherapy. Methods: A prospective observational study was carried out in the Departments of Pathology, Medicine, and Pediatrics, Universiti Kebangsaan Malaysia, Medical Center (UKMMC), Kuala Lumpur, Malaysia during a period of 19 months from April 2009 to December 2010 to assess the bone marrow recovery in patients with acute leukemia. A total of 22 patients in remission induction phases were enrolled in this study. The blood specimens were collected from day zero after chemotherapy, and every 3 days until patients recovered hematologically. All blood samples were measured for ANC and IRF using an automated hematology analyzer (Beckman-Coulter LH750). Results: The percentage of patients showing IRF recovery earlier than ANC recovery was 63.6% (14 out of 22 patients). There was a significant difference in the mean number of days for IRF recovery as compared with ANC recovery (14.05 and 17.18 days), p=0.005. Conclusion: This study proved that IRF was more useful in predicting bone marrow recovery in a patient with acute leukemia post induction chemotherapy compared with ANC. The IRF is not affected by infection, is easily measured, and inexpensive; thus, it is a reliable parameter to evaluate bone marrow reconstitution.en_US
dc.description.natureFinalen_US
dc.identifier.CODENSAMJD
dc.identifier.epage349
dc.identifier.issn3795284
dc.identifier.issue4
dc.identifier.pmid24749130
dc.identifier.scopus2-s2.0-84899656321
dc.identifier.spage346
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84899656321&partnerID=40&md5=7cb6892074636422c799a6ee2d9cc6b8
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/10138
dc.identifier.volume35
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherSaudi Arabian Armed Forces Hospitalen_US
dc.relation.ispartofSaudi Medical Journal
dc.sourceScopus
dc.titleImmature reticulocyte fraction is an early predictor of bone marrow recovery post chemotherapy in patients with acute leukemiaen_US
dc.title.alternativeSaudi Med. J.en_US
dc.typeArticleen_US
dspace.entity.typePublication

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