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Global fecal and plasma metabolic dynamics related to Helicobacter pylori eradication

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dc.Chemicals/CASamoxicillin, 26787-78-0, 34642-77-8, 61336-70-7; clarithromycin, 81103-11-9; levofloxacin, 100986-85-4, 138199-71-0; pantoprazole, 102625-70-7; rabeprazole, 117976-89-3, 117976-90-6
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversity of Malaya (UM)
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.affiliationsDeakin University
dc.contributor.affiliationsNew York University School of Medicines
dc.contributor.affiliationsNational University of Singapore
dc.contributor.authorYap T.W.-C.en_US
dc.contributor.authorLeow A.H.-R.en_US
dc.contributor.authorAzmi A.N.en_US
dc.contributor.authorCallahan D.L.en_US
dc.contributor.authorPerez-Perez G.I.en_US
dc.contributor.authorLoke M.-F.en_US
dc.contributor.authorGoh K.-L.en_US
dc.contributor.authorVadivelu J.en_US
dc.date.accessioned2024-05-28T08:38:58Z
dc.date.available2024-05-28T08:38:58Z
dc.date.issued2017
dc.description.abstractBackground: Helicobacter pylori colonizes the gastric mucosa of more than half of the world's population. There is increasing evidence H. pylori protects against the development of obesity and childhood asthma/allergies in which the development of these diseases coincide with transient dysbiosis. However, the mechanism underlying the association of H. pylori eradication with human metabolic and immunological disorders is not well-established. In this study, we aimed to investigate the local and systemic effects of H. pylori eradication through untargeted fecal lipidomics and plasma metabolomics approaches by liquid chromatography mass spectrometry (LC-MS). Results: Our study revealed that eradication of H. pylori eradication (i.e., loss of H. pylori and/or H. pylori eradication therapy) changed many global metabolite/lipid features, with the majority being down-regulated. Our findings primarily show that H. pylori eradication affects the host energy and lipid metabolism which may eventually lead to the development of metabolic disorders. Conclusion: These predictive metabolic signatures of metabolic and immunological disorders following H. pylori eradication can provide insights into dynamic local and systemic metabolism related to H. pylori eradication in modulating human health. � 2017 Yap, Leow, Azmi, Callahan, Perez-Perez, Loke, Goh and Vadivelu.en_US
dc.description.natureFinalen_US
dc.identifier.ArtNo536
dc.identifier.doi10.3389/fmicb.2017.00536
dc.identifier.issn1664302X
dc.identifier.issueMAR
dc.identifier.scopus2-s2.0-85016644593
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85016644593&doi=10.3389%2ffmicb.2017.00536&partnerID=40&md5=0c53ee35bd242ef0ddc7aae9fc75ad97
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/9229
dc.identifier.volume8
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherFrontiers Research Foundationen_US
dc.relation.ispartofOpen Accessen_US
dc.relation.ispartofFrontiers in Microbiology
dc.sourceScopus
dc.subjectFecalen_US
dc.subjectHelicobacter pylorien_US
dc.subjectLipidomicsen_US
dc.subjectMetabolomicsen_US
dc.subjectPlasmaen_US
dc.titleGlobal fecal and plasma metabolic dynamics related to Helicobacter pylori eradicationen_US
dc.title.alternativeFront. Microbiol.en_US
dc.typeArticleen_US
dspace.entity.typePublication

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