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Synthesis of novel 6-substituted-5,6-Dihydrobenzo[4,5] Imidazo[1,2-c] quinazoline compounds and evaluation of their properties

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dc.contributor.authorHasan, HAen_US
dc.contributor.authorAbdulmalek, Een_US
dc.contributor.authorSaleh, TAen_US
dc.contributor.authorRahman, MBAen_US
dc.contributor.authorShaari, KBen_US
dc.contributor.authorYamin, BMen_US
dc.contributor.authorChan, KWen_US
dc.date.accessioned2024-05-29T02:50:18Z
dc.date.available2024-05-29T02:50:18Z
dc.date.issued2019-10-05
dc.descriptionJournal of Molecular Structure Volume 1193, 5 October 2019, Pages 482-494en_US
dc.description.abstractNew 6-substituted-5,6-dihydrobenzo[4,5] imidazo[1,2-c] quinazoline compounds were synthesized using two different protocols: microwave-enhanced and classical heating methods. A comparison study that was set up to compare both the methods and the results showed that the microwave-assisted method produced a better percentage yield (up to 98%) in a very short reaction time (only a few minutes). All compounds were characterized by spectroscopic and elemental analysis. Only one compound was analyzed by single crystal X-ray diffraction despite the difficulties of getting good crystal even after several attempts. The X-ray crystallography results were chemically acceptable and confirmed the structure of benzimidazoquinazoline 5. Incidentally, the studied derivatives were found to emit a very nice blue light when exposed to UV-light. Therefore, a photoluminescence study was performed as a part of the characterization processes. Biological application as an antimicrobial and an antioxidant for the target analogues was performed. Some derivatives exhibited high antibacterial activity against studied Gram-positive strains, although they were not active against Gram-negative strains. Moreover, some of them showed excellent antioxidant activities against both of the studied antioxidant DPPH center dot and ABTS(center dot)(+) radicals. (C) 2019 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.molstruc.2019.04.111
dc.identifier.epage494
dc.identifier.isbn1872-8014
dc.identifier.issn0022-2860
dc.identifier.scopusWOS:000471652700053
dc.identifier.spage482
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/11036
dc.identifier.volume1193
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherElsevier Science BVen_US
dc.relation.ispartofJournal Of Molecular Structureen_US
dc.sourceWeb Of Science (ISI)
dc.subjectDihydrobenzo[4,5]imidazo[1,2-c]quinazolinen_US
dc.subjectAntioxidanten_US
dc.subjectAntimicrobialen_US
dc.subjectSingle crystalen_US
dc.subjectFluorescenceen_US
dc.titleSynthesis of novel 6-substituted-5,6-Dihydrobenzo[4,5] Imidazo[1,2-c] quinazoline compounds and evaluation of their propertiesen_US
dc.typeArticleen_US
dspace.entity.typePublication

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