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Antibacterial Activities Of Green Silver Nanoparticles-strobilanthes Crispus (AgNP-SC) Against Clinically Important Bacteria

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dc.contributor.authorRohazila Mohamad Hanafiahen_US
dc.contributor.authorSiti Nor Asma Musaen_US
dc.contributor.authorSiti Aisyah Abd Ghafaren_US
dc.date.accessioned2024-05-28T03:33:02Z
dc.date.available2024-05-28T03:33:02Z
dc.date.issued2019
dc.date.submitted29/1/2020
dc.descriptionMalaysian Journal of Medicine and Health Sciences Vol.15 Supp 8, November 2019 (eISSN 2636-9346) Proceedings of the 2nd ICOMOI 19-20 Nov 2019en_US
dc.description.abstractIntroduction: Silver nanoparticles has been proven to be an effective agent for antimicrobial efficacy against bacteria, viruses and other eukaryotic microorganisms. Green synthesis is one of the methods that has been developed to synthesize silver nanoparticles in environmentally-friendly conditions. It uses plant extracts as reducing and capping agents. Besides act as reducing and capping agents, bioactives such as phenolic compounds may bind to silver nanoparticles and enhance its medicinal properties. Strobilanthes crispus is a Malaysian native plant. Previous studies had shown that S. crispus contains polyphenols, catechins, alkaloids, caffeine, tannins and vitamins. Therefore, the aim of this study is to determine antibacterial activities of silver nanoparticles-Strobilanthes crispus (AgNP-SC) against clinically important pathogens such as Escherichia coli, Pseudomonas aeruginosa and Streptococcus mutans. Methods: The disc diffusion assay (DDA) was performed to investigate the inhibition zone of AgNps-Sc towards E. coli, P. aeruginosa and S. mutans. Minimum inhibition concentration (MIC) and minimum bactericidal concentration (MBC) was used to determine bactericidal/bacteriostatic profile of AgNP- SC against E. coli, P. aeruginosa and S. mutans. Results: AgNP-SC (40mg/mL) shows the greatest inhibition properties (12.67±0.6mm) against S. mutans when compared to Strobilanthes crispus leaves extract (6.0±0.001mm) and blank silver nanoparticles (6.0±0.001mm). MIC values for AgNP-SC against S. mutans and E. coli were at 0.625 mg/mL and 1.25 mg/mL, respectively. Whereas the MIC value of AgNP- SC against P. aeruginosa was at 2.5 mg/mL. MBC values of AgNP-SC against E. coli, P. aeruginosa and S. mutans were at 1.25, 2.5 mg/mL respectively. Results are concentration-dependent, with higher concentration demonstrating better inhibition property. Conclusion: It can be concluded that AgNP-SC possesses bactericidal properties against S. mutans, E. coli and P. aeruginosa.en_US
dc.identifier.epage0
dc.identifier.issn1675-8544
dc.identifier.issue8
dc.identifier.other1815-19
dc.identifier.spage40
dc.identifier.urichrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/viewer.html?pdfurl=https%3A%2F%2Fmedic.upm.edu.my%2Fupload%2Fdokumen%2F20191129102937Complete_file_2nd_ICOMOI_2019.pdf&clen=294332&chunk=true
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/4656
dc.identifier.volume15
dc.language.isoenen_US
dc.publisherUPMen_US
dc.relation.conferenceProceedings of the 2nd ICOMOI 19-20 Nov 2019en_US
dc.relation.ispartofMalaysian Journal of Medicine and Health Sciencesen_US
dc.titleAntibacterial Activities Of Green Silver Nanoparticles-strobilanthes Crispus (AgNP-SC) Against Clinically Important Bacteriaen_US
dc.typeArticleen_US
dspace.entity.typePublication

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