Publication:
The Action Of Coleus Aromaticus As A Potential Wound Healing Agent In Experimentally Induced Diabetic Mice

Simple item page
dc.contributor.authorKalesware Muniandyen_US
dc.contributor.authorZaiton Hassan2en_US
dc.contributor.authorMohd Hafez Mohd Isaen_US
dc.date.accessioned2024-05-28T03:30:44Z
dc.date.available2024-05-28T03:30:44Z
dc.date.issued2014
dc.descriptionPERINTIS E-Journal, 2014, Vol. 4, No. 1, pp.1-30en_US
dc.description.abstractThe ethanolic and aqueous extract of Coleus aromaticusleaves and roots wereevaluated for its wound healing activity in diabetic mice inducedexperimentallywith Monosodium Glutamate (MSG) viaexcision and dead space wound modelswith the application of 100 mg kg-1of body weight of extract. Excision wound was createdon five different groups of mice and the wound contractionwas measured for ten uninterrupteddays. Dead space wound model was performed on four different groups of mice for the estimation of the weight of both wet and dry granulation tissue followed by the histological investigation of the wet granulation tissue after ten days. Ethanolic extract treated wounds showed 76.6% of wound area reduction compared to thecontrols that only showed 55.9 % of wound area reduction. The rate of epithelialization in ethanolic extract treated mice was interestingly higher compared to the controls. Histological investigation shows an increase in granulation tissue, good proliferation of collagen tissue and satisfactory angiogenesis in the leaves and root extract treated mice compared to the controls. Coleus aromaticusstimulates significant wound healing in experimentally induced diabetic mice and evaluation of the effectiveness ofColeus aromaticus as wound healingagenton humanorganismis highly suggested. Keywords:wound healing;Coleus aromaticus; excision wound model; dead space wound model;epithelializationen_US
dc.identifier.epage30
dc.identifier.issn2232-0725
dc.identifier.issue1
dc.identifier.other313-17
dc.identifier.spage1
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/4537
dc.identifier.volume4
dc.language.isoenen_US
dc.publisherPersatuan Saintis Muslim Malaysiaen_US
dc.relation.ispartofPERINTIS E-Journalen_US
dc.subjectwound healing;en_US
dc.subjectColeus aromaticus;en_US
dc.subjectexcision wound model;en_US
dc.subjectdead space wound model;en_US
dc.subjectepithelializationen_US
dc.titleThe Action Of Coleus Aromaticus As A Potential Wound Healing Agent In Experimentally Induced Diabetic Miceen_US
dc.typeArticleen_US
dspace.entity.typePublication

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
313-6cnfy_The Action Of Coleus Aromaticus As A Potential Wound Healing Agent In Experimentally.pdf
Size:
638.4 KB
Format:
Adobe Portable Document Format
Description:
The Action Of Coleus Aromaticus As A Potential Wound Healing Agent In Experimentally Induced Diabetic Mice
Download

Collections

Other Publications