Publication:
Budget Impact Analysis Of Two Treatment Approaches For Hepatitis C In Malaysia Through The Use Of Voluntary And Compulsory Licensing Options

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dc.contributor.authorAmirah Azzer
dc.contributor.authorMaznah Dahlui
dc.contributor.authorRosmawati Mohamed
dc.contributor.authorScott Alexander McDonald
dc.contributor.authorHafiz Jaafar
dc.contributor.authorFatiha Hana Shabaruddin
dc.date.accessioned2024-06-16T06:33:39Z
dc.date.available2024-06-16T06:33:39Z
dc.date.issued2023
dc.date.submitted2024-1-29
dc.descriptionFront. Public Health Volume 11 Page (1-9)
dc.description.abstractIntroduction: A scaled-up treatment cascade with direct-acting antiviral (DAA therapy is necessary to achieve global WHO targets for hepatitis C virus (HCV) elimination in Malaysia. Recently, limited access to sofosbuvir/daclatasvir (SOF/DAC) is available through compulsory licensing, with access to sofosbuvir/velpatasvir (SOF/VEL) expected through voluntary licensing due to recent agreements. SOF/VEL has superior clinical outcomes but has higher drug acquisition costs compared to SOF/DAC. A stratified treatment cascade might be the most cost-e cient approach for Malaysia whereby all HCV patients are treated with SOF/DAC except for patients with cirrhosis who are treated with SOF/VEL. Methods: This study aimed to conduct a 5-year budget impact analysis of the proposed stratified treatment cascade for HCV treatment in Malaysia. A disease progression model that was developed based on model-predicted HCV epidemiology data was used for the analysis, where all HCV patients in scenario A were treated with SOF/DAC for all disease stages while in scenario B, SOF/DAC was used only for non-cirrhotic patients and SOF/VEL was used for the cirrhotic patients. Healthcare costs associated with DAA therapy and disease stage monitoring were included to estimate the downstream cost implications. Results: The stratified treatment cascade with 109 in Scenario B was found to be cost-saving compared to Scenario A. The cumulative savings for the stratified treatment cascade was USD 1.4 million over 5 years. Discussion: A stratified treatment cascade with SOF/VEL was expected to be cost-saving and can result in a budget impact reduction in overall healthcare expenditure in Malaysia.
dc.identifier.citationAmirah Azzeri, Maznah Dahlui, Rosmawati Mohamed McDonald SA,Hafiz Jaafar & Fatiha Hana Shabaruddin H (2023) Budget impact analysis of two treatment approaches for hepatitis C in Malaysia through the use of voluntary and compulsory licensing options. Front. Public Health 11:1114560. doi: 10.3389/fpubh.2023.1114560
dc.identifier.doi10.3389/fpubh.2023.1114560
dc.identifier.epage9
dc.identifier.issn2296-2565
dc.identifier.issue1114560
dc.identifier.other2446-15
dc.identifier.spage1
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/19809
dc.identifier.volume11
dc.language.isoen_US
dc.publisherFrontiers
dc.relation.ispartofFrontiers in Public Health
dc.relation.issn2296-2565
dc.relation.journalFront. Public Health
dc.subjecthepatitis C
dc.subjectdirect acting antiviral
dc.subjecteconomic burden
dc.subjectbudget impact analysis
dc.subjectMalaysia
dc.titleBudget Impact Analysis Of Two Treatment Approaches For Hepatitis C In Malaysia Through The Use Of Voluntary And Compulsory Licensing Options
dc.typetext::journal::journal article
dspace.entity.typePublication
oaire.citation.endPage9
oaire.citation.startPage1
oaire.citation.volume11
oairecerif.author.affiliationUniversiti Sains Islam Malaysia
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#
oairecerif.author.affiliationUniversiti Sains Islam Malaysia
oairecerif.author.affiliation#PLACEHOLDER_PARENT_METADATA_VALUE#

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