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Massive chronic intervillositis of the placenta: A rare placental lesion with high risk of recurrences

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dc.contributor.authorNazifah Adnanen_US
dc.contributor.authorNur Syahrina Binti Rahimen_US
dc.contributor.authorValyakalayil Daniel Philipen_US
dc.contributor.authorHayati Binti Abd Rahmanen_US
dc.date.accessioned2024-05-27T14:37:49Z
dc.date.available2024-05-27T14:37:49Z
dc.date.issued2016
dc.description.abstractIntroduction: Massive chronic intervillositis (MCV) or currently known as chronic intervillositis of unknown aetiology is a rare poorly understood placental lesion. MCV is strongly associated with recurrent spontaneous miscarriages, IUGR and fetal demise. We described a case of MCV in a lady with consecutive recurrent miscarriages. Case report: The patient was a 37-year-old lady who had ten consecutive recurrent first trimester miscarriages within the last 13 years. She has no living child and the relevant blood investigations were not helpful in determining the cause of recurrent miscarriages. Histopathological examination of the conception tissues showed abundant aggregates of CD 68 positive histiocytes primarily within the intervillous spaces associated with increased perivillous fibrin deposition. No significant villitis were seen. The findings were consistent with massive chronic intervillositis. Discussion & conclusion: MCV is associated with high recurrence rate of spontaneous miscarriages. In general, practicing pathologist are unfamiliar with MCV. The histiocytes may be missed during a routine reporting of tissue from products of conception if important clinical informations are not being highlighted to the pathologists. Chronic intervillositis of infectious etiology should be excluded. However the etiology of MCV remains unclear. The histiocytes are maternal in origin which led to the hypothesis of a possible abnormal maternal immune reaction towards the placental tissue in the pathogenesis of MCV. Obstetricians and pathologists should be made aware of this entity. Until today, no proven effective treatment has been proposed to prevent recurrences. Further studies are required in the understanding of this entity and in the prevention of recurrent pregnancy losses.en_US
dc.identifier.citationAdznan, Nazifah & Rahim, Nur & Philip, Valyakalayil & Rahman, Hayati. (2016). Massive chronic intervillositis of the placenta: A rare placental lesion with high risk of recurrences.en_US
dc.identifier.epage210
dc.identifier.issn0126-8635
dc.identifier.issue2
dc.identifier.spage210
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/3484
dc.identifier.volume38
dc.language.isoen_USen_US
dc.publisherCollege of Pathologistsen_US
dc.relation.conferenceThe 15 th Annual Scientiļ¬c Meeting of the College of Pathologists, Academy ofMedicine Malaysia was held at Pullman Putrajaya Lakeside Hotel, Putrajaya,Malaysia on 3-5 June 2016en_US
dc.relation.ispartofMalaysian Journal Pathologyen_US
dc.titleMassive chronic intervillositis of the placenta: A rare placental lesion with high risk of recurrencesen_US
dc.typeArticleen_US
dspace.entity.typePublication

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