Publication:
The Role of Urocortins in Intracerebral Hemorrhage

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dc.contributor.authorKer Woon Choyen_US
dc.contributor.authorAndy Po-Yi Tsaien_US
dc.contributor.authorPeter Bor-Chian Linen_US
dc.contributor.authorMeng-Yu Wuen_US
dc.contributor.authorChihyi Leeen_US
dc.contributor.authorAspalilah Aliasen_US
dc.contributor.authorCheng-Yoong Pangen_US
dc.contributor.authorHock-Kean Liewen_US
dc.date.accessioned2024-05-29T02:59:44Z
dc.date.available2024-05-29T02:59:44Z
dc.date.issued2020
dc.description.abstractIntracerebral hemorrhage (ICH) causes an accumulation of blood in the brain parenchyma that disrupts the normal neurological function of the brain. Despite extensive clinical trials, no medical or surgical therapy has shown to be effective in managing ICH, resulting in a poor prognosis for the patients. Urocortin (UCN) is a 40-amino-acid endogenous neuropeptide that belongs to the corticotropin-releasing hormone (CRH) family. The effect of UCN is activated by binding to two G-protein coupled receptors, CRH-R1 and CRH-R2, which are expressed in brain neurons and glial cells in various brain regions. Current research has shown that UCN exerts neuroprotective effects in ICH models via anti-inflammatory effects, which generally reduced brain edema and reduced blood-brain barrier disruption. These effects gradually help in the improvement of the neurological outcome, and thus, UCN may be a potential therapeutic target in the treatment of ICH. This review summarizes the data published to date on the role of UCN in ICH and the possible protective mechanisms underlined.en_US
dc.identifier.doi10.3390/biom10010096
dc.identifier.isbn2218-273X
dc.identifier.issue1
dc.identifier.scopusWOS:000514863200048
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/11751
dc.identifier.volume10
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherMdpien_US
dc.relation.ispartofBiomoleculesen_US
dc.subjectcorticotropin-releasing hormone receptoren_US
dc.subjectendogenous neuropeptideen_US
dc.subjectintracerebral hemorrhageen_US
dc.subjectneuroprotectiveen_US
dc.subjecturocortinen_US
dc.titleThe Role of Urocortins in Intracerebral Hemorrhageen_US
dspace.entity.typePublication

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