Publication:
The Effects of Ficus Carica Fruit on Bone Markers and Oestrogen Level of Post-Menopausal Osteoporotic Rats

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dc.contributor.authorIzzaty, RNen_US
dc.contributor.authorAdlina, MNen_US
dc.contributor.authorDzulkhairi, MRMen_US
dc.contributor.authorShamsir MAMen_US
dc.contributor.authorNadia, MEen_US
dc.date.accessioned2024-05-29T02:50:42Z
dc.date.available2024-05-29T02:50:42Z
dc.date.issued2019
dc.description.abstractIntroduction: Post-menopausal osteoporosis is the most common type of osteoporosis, which occurs due to a deficiency of oestrogen following menopause. Considering the adverse effects of oestrogen replacement therapy, natural products may serve to replace the current conventional treatment. Ficus carica (FC) which is commonly known as fig may have a potential in treating post-menopausal osteoporosis due to their abundance of important minerals and bioactive compounds such as phenolic, flavonoid and anthocyanins. This study aimed to evaluate the effects of FC on bone metabolism of ovariectomized rats. Materials and Methods: Fifty-six female Spraque-Dawley rats were randomly divided into seven groups; SHAM operated (SHAM), ovariectomized control (OVX), ovariectomized + 64.5 mu g/kg oestrogen (ERT), ovariectomized + 50 mg/kg aqueous extract of FC (AQ50), ovariectomized + 100 mg/kg aqueous extract of FC (AQ100), ovariectomized + 50 mg/kg raw FC (RW50), and ovariectomized + 100 mg/kg raw FC (RW100). After eight weeks of treatments, rats were euthanized and femurs were dissected out to measure bone osteocalcin, Ctelopeptide of type 1 collagen and bone estrogen level. Results: RW50 and RW100 showed an increasing trend in osteocalcin levels and also oestrogen level, but no significant difference between all groups. RW50 and RW100 also showed significantly reduced C-telopeptide of type 1 collagen levels compared to OVX group. Conclusion: These findings suggested that raw FC at the doses of 50 mg/kg and 100 mg/kg have potential to improve bone in treating post-menopausal osteoporosis. However, this need to be confirmed with higher doses.en_US
dc.identifier.epage104
dc.identifier.issn1823-4631
dc.identifier.issue1
dc.identifier.scopusWOS:000465628000012
dc.identifier.spage97
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/11100
dc.identifier.volume18
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherInt Islamic Univ Malaysia, Kulliyyah Medicineen_US
dc.relation.ispartofInternational Medical Journal Malaysiaen_US
dc.sourceWeb Of Science (ISI)
dc.subjectpost-menopausal osteoporosisen_US
dc.subjectFicus caricaen_US
dc.subjectbone markeren_US
dc.subjectosteocalcinen_US
dc.subjectCTX-1en_US
dc.titleThe Effects of Ficus Carica Fruit on Bone Markers and Oestrogen Level of Post-Menopausal Osteoporotic Ratsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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