Publication:
Neurotrophin-3 and Neurotrophin-4: The Unsung Heroes that Lies behind the Meninges

Simple item page
dc.contributor.authorNoor Azzizah Omaren_US
dc.contributor.authorJaya Kumaren_US
dc.contributor.authorSeong Lin Teohen_US
dc.date.accessioned2024-05-29T02:26:05Z
dc.date.available2024-05-29T02:26:05Z
dc.date.issued2022
dc.date.submitted2023-9-29
dc.descriptionVolume 92en_US
dc.description.abstractNeurotrophin is a growth factor that regulates the development and repair of the nervous system. From all factors, two pioneer groups, the nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF), have been widely explored for their role in disease pathogenesis and potential use as therapeutic agents. Nonetheless, neurotrophin-3 (NT3) and neurotrophin-4 (NT4) also have promising potential, albeit less popular than their counterparts. This review focuses on the latter two factors and their roles in the pathogenesis of brain disorders and potential therapies. An extensive literature search of NT3 and NT4 with their receptors, the TrkB and TrkC on the nervous system were extracted and analyzed. We found that NT3 and NT4 are not only involved in the pathogenesis of some neurodegenerative diseases, but also have promising therapeutic potential on injury- and vascular-related nervous system disease, neuropsychiatry, neurodegeneration and peripheral nerve diseases. In conclusion, the role of NT3 and NT4 should be further emphasized, and more studies could be explored on the potential use of these neurotrophins in the human study.en_US
dc.identifier.doi10.1016/j.npep.2022.102226
dc.identifier.epage11
dc.identifier.issn0143-4179
dc.identifier.issue2022
dc.identifier.spage1
dc.identifier.urihttps://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0143417922000014?returnurl=https:%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0143417922000014%3Fshowall%3Dtrue&referrer=https:%2F%2Foarep.usim.edu.my%2F
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85122519894&origin=resultslist&sort=plf-f&src=s&sid=45b56922a4965250340359298d8843c6&sot=b&sdt=b&s=TITLE-ABS-KEY%28Neurotrophin-3+And+Neurotrophin-4%3A+The+Unsung+Heroes+That+Lies+Behind+The+Meninges%29&sl=97&sessionSearchId=45b56922a4965250340359298d8843c6
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/10563
dc.identifier.volume92
dc.language.isoen_USen_US
dc.publisherElseiveren_US
dc.relation.ispartofNeuropeptidesen_US
dc.subjectCerebrovascular accident; Neurodegenerative disease; Neuroprotection; Neuropsychiatry disease; Peripheral nerve disease; Spinal cord injury; Traumatic brain injuryen_US
dc.titleNeurotrophin-3 and Neurotrophin-4: The Unsung Heroes that Lies behind the Meningesen_US
dc.typeArticleen_US
dspace.entity.typePublication

Files

Collections

Scopus