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Metabolomics Profiling of Age-associated Metabolites in Malay Population

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dc.contributor.authorJen Kit Tanen_US
dc.contributor.authorSiti Nor Asyikin Zakariaen_US
dc.contributor.authorGeetha Gunasekaranen_US
dc.contributor.authorNur Fathiah Abdul Sanien_US
dc.contributor.authorMuhammad Luqman Nasaruddinen_US
dc.contributor.authorFaizul Jaafaren_US
dc.contributor.authorZulzikry Hafiz Abu Bakaren_US
dc.contributor.authorAhmad Imran Zaydi Amir Hamzahen_US
dc.contributor.authorKhairun Nain Nor Aripinen_US
dc.contributor.authorMohd Dzulkhairi Mohd Ranien_US
dc.contributor.authorNor Azila Nohen_US
dc.contributor.authorHanafi Ahmad Damanhurien_US
dc.contributor.authorMusalmah Mazlanen_US
dc.contributor.authorSuzana Makpolen_US
dc.contributor.authorWan Zurinah Wan Ngahen_US
dc.date.accessioned2024-05-29T02:02:16Z
dc.date.available2024-05-29T02:02:16Z
dc.date.issued2023
dc.date.submitted2023-2-9
dc.descriptionVolume 2023en_US
dc.description.abstractAging is a complex process characterized by progressive loss of functional abilities due to the accumulation of molecular damages. Metabolomics could offer novel insights into the predictors and mechanisms of aging. This cross-sectional study is aimed at identifying age-associated plasma metabolome in a Malay population. A total of 146 (90 females) healthy participants aged 28–69 were selected for the study. Untargeted metabolomics profiling was performed using liquid chromatography-tandem mass spectrometry. Association analysis was based on the general linear model. Gender-associated metabolites were adjusted for age, while age-associated metabolites were adjusted for gender or analyzed in a gender-stratified manner. Gender-associated metabolites such as 4-hydroxyphenyllactic acid, carnitine, cortisol, and testosterone sulfate showed higher levels in males than females. Deoxycholic acid and hippuric acid were among the metabolites with a positive association with age after being adjusted for gender, while 9(E),11(E)-conjugated linoleic acid, cortisol, and nicotinamide were negatively associated with age. In gender-stratified analysis, glutamine was one of the common metabolites that showed a direct association with age in both genders, while metabolites such as 11-deoxy prostaglandin F2β, guanosine monophosphate, and testosterone sulfate were inversely associated with age in males and females. This study reveals several age-associated metabolites in Malays that could reflect the changes in metabolisms during aging and may be used to discern the risk of geriatric syndromes and disorders later. Further studies are required to determine the interplay between these metabolites and environmental factors on the functional outcomes during aging.en_US
dc.identifier.doihttps://doi.org/10.1155/2023/4416410
dc.identifier.epage12
dc.identifier.issn1942-0900
dc.identifier.spage1
dc.identifier.urihttps://www.hindawi.com/journals/omcl/2023/4416410/
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85148113584&origin=resultslist&sort=plf-f&src=s&sid=65805d33bfd3843ab8a07a8c6783b793&sot=b&sdt=b&s=TITLE-ABS-KEY%28Metabolomics+Profiling+Of+Age-associated+Metabolites+In+Malay+Population%29&sl=87&sessionSearchId=65805d33bfd3843ab8a07a8c6783b793
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/10207
dc.identifier.volume2023
dc.language.isoen_USen_US
dc.publisherHindawien_US
dc.relation.ispartofOxidative Medicine and Cellular Longevityen_US
dc.titleMetabolomics Profiling of Age-associated Metabolites in Malay Populationen_US
dc.typeArticleen_US
dspace.entity.typePublication

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