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Exploring cortical plasticity and oscillatory brain dynamics via transcranial magnetic stimulation and resting-state electroencephalogram

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dc.citedby3
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.authorNoh N.A.en_US
dc.date.accessioned2024-05-28T08:39:29Z
dc.date.available2024-05-28T08:39:29Z
dc.date.issued2016
dc.description.abstractTranscranial magnetic stimulation (TMS) is a non-invasive, non-pharmacological technique that is able to modulate cortical activity beyond the stimulation period. The residual aftereffects are akin to the plasticity mechanism of the brain and suggest the potential use of TMS for therapy. For years, TMS has been shown to transiently improve symptoms of neuropsychiatric disorders, but the underlying neural correlates remain elusive. Recently, there is evidence that altered connectivity of brain network dynamics is the mechanism underlying symptoms of various neuropsychiatric illnesses. By combining TMS and electroencephalography (EEG), the functional connectivity patterns among brain regions, and the causal link between function or behaviour and a specific brain region can be determined. Nonetheless, the brain network connectivity are highly complex and involve the dynamics interplay among multitude of brain regions. In this review article, we present previous TMS-EEG co-registration studies, which explore the functional connectivity patterns of human cerebral cortex. We argue the possibilities of neural correlates of long-term potentiation/ depression (LTP-/LTD)-like mechanisms of synaptic plasticity that drive the TMS aftereffects as shown by the dissociation between EEG and motor evoked potentials (MEP) cortical output. Here, we also explore alternative explanations that drive the EEG oscillatory modulations post TMS. The precise knowledge of the neurophysiological mechanisms underlying TMS will help characterise disturbances in oscillatory patterns, and the altered functional connectivity in neuropsychiatric illnesses. � Penerbit Universiti Sains Malaysia, 2016.en_US
dc.description.natureFinalen_US
dc.identifier.CODENMJMSA
dc.identifier.doi10.21315/mjms2016.23.4.2
dc.identifier.epage16
dc.identifier.issn1394195X
dc.identifier.issue4
dc.identifier.scopus2-s2.0-84982938236
dc.identifier.spage5
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84982938236&doi=10.21315%2fmjms2016.23.4.2&partnerID=40&md5=7f88e196c94a6e913589d1a7d177834d
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/9242
dc.identifier.volume23
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherPenerbit Universiti Sains Malaysiaen_US
dc.relation.ispartofOpen Accessen_US
dc.relation.ispartofMalaysian Journal of Medical Sciences
dc.sourceScopus
dc.subjectBrain stimulationen_US
dc.subjectLong-term depression (LTD)en_US
dc.subjectLong-term potentiation (LTP)en_US
dc.subjectOscillationsen_US
dc.subjectPlasticityen_US
dc.titleExploring cortical plasticity and oscillatory brain dynamics via transcranial magnetic stimulation and resting-state electroencephalogramen_US
dc.title.alternativeMalays. J. Med. Sci.en_US
dc.typeReviewen_US
dspace.entity.typePublication

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