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Effects of Sargassum oligocystum and Padina australis extract on adipogenesis and adipolysis in 3T3-L1 cells

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dc.contributor.affiliationsFaculty of Dentistry
dc.contributor.affiliationsInternational Islamic University Malaysia (IIUM)
dc.contributor.affiliationsSurya University
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.authorJaswir I.en_US
dc.contributor.authorAhmad H.en_US
dc.contributor.authorSusanti D.en_US
dc.contributor.authorBakhtiar M.T.en_US
dc.contributor.authorOctavianti F.en_US
dc.date.accessioned2024-05-28T08:33:46Z
dc.date.available2024-05-28T08:33:46Z
dc.date.issued2017
dc.description.abstractIn recent years, the search for natural, safe and effective therapies for the management of obesity has become important. The present study investigated the potential of brown seaweeds Sargassum oligocystum and Padina australis from Malaysian waters as natural alternatives for the management of obesity. Both seaweeds were macerated using acetone at room temperature for ten hours. The S. oligocystum extracts (SE) and P. australis extracts (PE) were then applied to 3T3-L1 cells during the differentiation stage and during the mature stage of the adipocyte life cycle to assess the effects of extracts on adipogenesis and adipolysis. Application of SE at 12.5 and 50 ?g/ml to the cells decreased adipogenesis by 71.7%, and 84.8%, respectively, while cells treated with 12.5 and 50 ?g/ml PE showed 85.7%, and 89.0% adipogenesis respectively, compared to control. Application of SE and PE to mature lipid cells stimulated adipolysis and the release of glycerol into the culture media. Application of SE at 12.5 and 50 ?g ?g/ml in the cell media induced glycerol release by up to 88.6 and 93.0%, respectively, while PE increased glycerol release up to 92.9 and 95.6% respectively, compared to isoproterenol. This study demonstrates the potential of whole brown seaweed extracts from S. oligocystum and P. australis collected from Malaysian waters as natural anti- obesity agents. Incorporation of the brown seaweed into the diet as a functional food will be useful for prevention and treatment of obesity. � All Rights Reserved.en_US
dc.description.natureFinalen_US
dc.identifier.epage401
dc.identifier.issn19854668
dc.identifier.scopus2-s2.0-85043511204
dc.identifier.spage395
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85043511204&partnerID=40&md5=a6593cebcff3a4b506a8a4e4d6110823
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/9069
dc.identifier.volume24
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherUniversiti Putra Malaysiaen_US
dc.relation.ispartofInternational Food Research Journalen_US
dc.sourceScopus
dc.subjectAdipogenesisen_US
dc.subjectAdipolysisen_US
dc.subjectBrown seaweedsen_US
dc.subjectExtractionen_US
dc.titleEffects of Sargassum oligocystum and Padina australis extract on adipogenesis and adipolysis in 3T3-L1 cellsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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