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In-vitro inhibitory effect of Cinnamomum zeylanicum and Eugenia caryophyllata Oils on Multispecies Anaerobic Oral Biofilm

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dc.contributor.affiliationsFaculty of Dentistry
dc.contributor.affiliationsUniversiti Kebangsaan Malaysia (UKM)
dc.contributor.affiliationsMinistry of Health Malaysia
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.authorAzizan N.en_US
dc.contributor.authorMohd-Said S.en_US
dc.contributor.authorFirdaus Mazlan M.K.en_US
dc.contributor.authorChelvan K.T.en_US
dc.contributor.authorHanafiah, Rohazila Mohamaden_US
dc.contributor.authorZainal-Abidin Z.en_US
dc.date.accessioned2024-05-29T02:07:52Z
dc.date.available2024-05-29T02:07:52Z
dc.date.issued2019
dc.descriptionJ Int Dent Med Res 2019; 12(2): 411-417en_US
dc.description.abstractThe study aimed to determine the in-vitro inhibitory effect of Cinnamomum zeylanicum Blume (cinnamon) and Eugenia caryophyllata (clove) oils on combined Porphyromonas gingivalis and Fusobacterium nucleatum biofilm. Following a steam distillation extraction technique, oils from cinnamon bark and clove buds were tested for their antibacterial anti-adhesion and anti-biofilm activities on mixed biofilm containing P.gingivalis and F.nucleatum. The quantification of viable and adhered bacterial cells on 96-well plates using the crystal violet test was analysed and morphology of the bacteria in biofilm was observed under the scanning electron microscope (SEM). Our study demonstrated C.zeylanicum oil inhibited satisfactory anti-adhesion effect and significantly disrupted the biofilm formation at 1.25-5.0 mg/mL whereas E.caryophyllata oil suppressed the adhesion of bacteria and disrupted the formation of biofilm at 0.63-5.0 mg/mL. The SEM study showed prominent changes including ruptures and flatten bacterial wall in samples with E.caryophyllata oil while pitted and flatten cells were seen in C.zeylanicum samples compared to the smooth and distinguished cell wall seen in untreated samples or even more damaged cells in Ampicillin samples. We conclude that C.zeylanicum and E.caryophyllata oils showed significant in vitro anti-biofilm properties against mixed P.gingivalis and F.nucleatum biofilm and prominently altered the bacterial wall morphology. This finding may suggest potential therapeutic properties of these oils in controlling biofilm-related oral diseases. 2019 Journal of International Dental and Medical Research.en_US
dc.description.natureFinalen_US
dc.identifier.epage417
dc.identifier.issn1309100X
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85069466454
dc.identifier.spage411
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85069466454&partnerID=40&md5=0118f7f7f1aeea9cb82de5b9c94c4bf9
dc.identifier.urichrome-extension://efaidnbmnnnibpcajpcglclefindmkaj/viewer.html?pdfurl=http%3A%2F%2Fwww.jidmr.com%2Fjournal%2Fwp-content%2Fuploads%2F2019%2F07%2F7_D18_692_SHAHIDA_MOHD_SAID_layout.pdf&clen=701086&chunk=true
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/10411
dc.identifier.volume12
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherUniversity of Dicleen_US
dc.relation.ispartofJournal of International Dental and Medical Researchen_US
dc.sourceScopus
dc.subjectBiofilmen_US
dc.subjectCinnamonen_US
dc.subjectCloveen_US
dc.subjectElectron microscopyen_US
dc.subjectPeriodontitisen_US
dc.titleIn-vitro inhibitory effect of Cinnamomum zeylanicum and Eugenia caryophyllata Oils on Multispecies Anaerobic Oral Biofilmen_US
dc.typeArticleen_US
dspace.entity.typePublication

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