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In vivo Assessment of Antioxidant and Wound Healing Improvement of a New Schiff Base Derived Co (II) Complex in Rats

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dc.contributor.authorEl-Ferjani, RMen_US
dc.contributor.authorAhmad, Men_US
dc.contributor.authorDhiyaaldeen, SMen_US
dc.contributor.authorHarun, FWen_US
dc.contributor.authorIbrahim, MYen_US
dc.contributor.authorAdam, Hen_US
dc.contributor.authorYamin, BMen_US
dc.contributor.authorAl-Obaidi, MMJen_US
dc.contributor.authorAl Batran, Ren_US
dc.date.accessioned2024-05-29T02:53:27Z
dc.date.available2024-05-29T02:53:27Z
dc.date.issued2016
dc.description.abstractCo (II) complex (CMLA) was investigated to evaluate the rate of wound healing in rats. Animals were placed into four groups: gum acacia, Intrasite gel, 10 and 20 mg/ml of CMLA. Wounds were made on the dorsal neck area, then treated with Intrasite gel or CMLA; both of these treatments led to faster healing than with gum acacia. Histology of the wounds dressed with CMLA or Intrasite gel displayed a smaller scar width, required less time to heal and showed more collagen staining and fewer inflammatory cells in comparison to wounds dressed with the vehicle. Immunohistochemistry for Hsp70 and TGF-beta showed greater staining intensity in the treated groups compared to the vehicle group. Bax staining was less intense in treated groups compared to the vehicle group, suggesting that CMLA and Intrasite gel provoked apoptosis, responsible for the development of granulation tissue into a scar. CD31 protein analysis showed that the treated groups enhanced angiogenesis and increased vascularization compared to the control group. Furthermore, a significant increase in the levels of GPx and SOD and a decrease in MDA were also observed in the treated groups. This results suggest that CMLA is a potentially promising agent for the wounds treatment.
dc.identifier.doi10.1038/srep38748
dc.identifier.issn2045-2322
dc.identifier.scopusWOS:000389677500001
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/11394
dc.identifier.volume6
dc.languageEnglish
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofScientific Reports
dc.sourceWeb Of Science (ISI)
dc.titleIn vivo Assessment of Antioxidant and Wound Healing Improvement of a New Schiff Base Derived Co (II) Complex in Rats
dc.typeArticleen_US
dspace.entity.typePublication

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