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Long lasting modulation of cortical oscillations after continuous theta burst transcranial magnetic stimulation

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dc.citedby50
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversity of Leicester
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.affiliationsUniversity of Verona
dc.contributor.authorNoh N.A.en_US
dc.contributor.authorFuggetta G.en_US
dc.contributor.authorManganotti P.en_US
dc.contributor.authorFiaschi A.en_US
dc.date.accessioned2024-05-29T02:05:04Z
dc.date.available2024-05-29T02:05:04Z
dc.date.issued2012
dc.description.abstractTranscranial magnetic theta burst stimulation (TBS) differs from other high-frequency rTMS protocols because it induces plastic changes up to an hour despite lower stimulus intensity and shorter duration of stimulation. However, the effects of TBS on neuronal oscillations remain unclear. In this study, we used electroencephalography (EEG) to investigate changes of neuronal oscillations after continuous TBS (cTBS), the protocol that emulates long-term depression (LTD) form of synaptic plasticity. We randomly divided 26 healthy humans into two groups receiving either Active or Sham cTBS as control over the left primary motor cortex (M1). Post-cTBS aftereffects were assessed with behavioural measurements at rest using motor evoked potentials (MEPs) and at active state during the execution of a choice reaction time (RT) task in combination with continuous electrophysiological recordings. The cTBS-induced EEG oscillations were assessed using event-related power (ERPow), which reflected regional oscillatory activity of neural assemblies of ? (4-7.5 Hz), low ? (8-9.5 Hz), ? (10-12.5 Hz), low ? (13-19.5 Hz), and high ? (20-30 Hz) brain rhythms. Results revealed 20-min suppression of MEPs and at least 30-min increase of ERPow modulation, suggesting that besides MEPs, EEG has the potential to provide an accurate cortical readout to assess cortical excitability and to investigate the interference of cortical oscillations in the human brain post-cTBS. We also observed a predominant modulation of ? frequency band, supporting the hypothesis that cTBS acts more on cortical level. Theta oscillations were also modulated during rest implying the involvement of independent cortical theta generators over the motor network post cTBS. This work provided more insights into the underlying mechanisms of cTBS, providing a possible link between synchronised neural oscillations and LTD in humans. � 2012 Noh et al.en_US
dc.description.natureFinalen_US
dc.identifier.ArtNoe35080
dc.identifier.doi10.1371/journal.pone.0035080
dc.identifier.issn19326203
dc.identifier.issue4
dc.identifier.pmid22496893
dc.identifier.scopus2-s2.0-84859336058
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84859336058&doi=10.1371%2fjournal.pone.0035080&partnerID=40&md5=53d7c3f879d65a59160fa9c60eca9eda
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/10317
dc.identifier.volume7
dc.languageEnglish
dc.language.isoen_USen_US
dc.relation.ispartofOpen Accessen_US
dc.relation.ispartofPLoS ONE
dc.sourceScopus
dc.titleLong lasting modulation of cortical oscillations after continuous theta burst transcranial magnetic stimulationen_US
dc.title.alternativePLoS ONEen_US
dc.typeArticleen_US
dspace.entity.typePublication

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