Publication:
Flavonoids Exhibit Potential Antagonistic Activity Against Platelet-Activating Factor (PAF) Receptor

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dc.contributor.authorNoraziah Nordinen_US
dc.contributor.authorAdib A.Abdullahen_US
dc.contributor.authorMohd F. A.Ghanien_US
dc.date.accessioned2024-05-28T06:06:27Z
dc.date.available2024-05-28T06:06:27Z
dc.date.issued2022
dc.date.submitted2023-1-10
dc.descriptionVol. 6 No. 10 (page:1626-1631)en_US
dc.description.abstractThe platelet-activating factor receptor (PAFR) has been a therapeutic target for platelet- activating factor (PAF)-mediated diseases. The pathophysiological condition is triggered by the interaction of PAF agonist. The discovery of PAF antagonists from natural flavonoids could be promising candidates for treating PAF-mediated diseases. Flavonoids that exist in most edible plants possess good health benefits to the human body. The study aimed to investigate the ability of three flavonoids (apigenin, galangin and fisetin) for molecular docking and dynamic simulations into PAFR protein. The PAFR-flavonoid complex binding affinities and interactions were assessed through molecular docking and dynamic simulations. Results found that all flavonoids significantly have a good binding affinity, ranging from - 9.1 to - 8.9 kcalmol-1. The stability of these flavonoids was also achieved in a 30 ns simulation. Four critical residues were detected in all PAFR-flavonoids complexes (Phe97, Phe98, Thr101 and Leu279) from the analysis of MMGBSA binding free energy. Interactions of van der Waals and electrostatic were seen by individual key residues of PAFR for the free energy contribution of ligands binding. All flavonoids showed promising anti-PAF candidate to be developed in the future.en_US
dc.identifier.citationNordin, N., F. A. Ghani, M., & A. Abdullah, A. (2022). Flavonoids Exhibit Potential Antagonistic Activity Against Platelet-Activating Factor (PAF) Receptor: http://www.doi.org/10.26538/tjnpr/v6i10.11. Tropical Journal of Natural Product Research (TJNPR), 6(10), 1626–1631. Retrieved from https://www.tjnpr.org/index.php/home/article/view/1214en_US
dc.identifier.doi10.26538/tjnpr/v6i10.11
dc.identifier.epage1631
dc.identifier.issn2616-0692
dc.identifier.issue10
dc.identifier.spage1626
dc.identifier.urihttps://www.tjnpr.org/index.php/home/article/view/1214
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/7059
dc.identifier.volume6
dc.language.isoen_USen_US
dc.publisherNatural Product Research Group, University of Beninen_US
dc.relation.ispartofTropical Journal of Natural Product Researchen_US
dc.subjectMethylglyoxal, AGEPs,Advanced glycation end products, Glutathione, Magnesium, Ubiquinone.en_US
dc.titleFlavonoids Exhibit Potential Antagonistic Activity Against Platelet-Activating Factor (PAF) Receptoren_US
dc.typeArticleen_US
dspace.entity.typePublication

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