Publication:
Theta-burst transcranial magnetic stimulation alters the functional topography of the cortical motor network

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dc.citedby4
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.affiliationsUniversity of Leicester
dc.contributor.affiliationsUniversity of Verona
dc.contributor.authorNoh N.A.en_US
dc.contributor.authorFuggetta G.en_US
dc.contributor.authorManganotti P.en_US
dc.date.accessioned2024-05-29T01:54:35Z
dc.date.available2024-05-29T01:54:35Z
dc.date.issued2015
dc.description.abstractBackground: Transcranial magnetic stimulation (TMS) is a non-invasive tool that is able to modulate the electrical activity of the brain depending upon its protocol of stimulation. Theta burst stimulation (TBS) is a high-frequency TMS protocol that is able to induce prolonged plasticity changes in the brain. The induction of plasticity-like effects by TBS is useful in both experimental and therapeutic settings; however, the underlying neural mechanisms of this modulation remain unclear. The aim of this study was to investigate the effects of continuous TBS (cTBS) on the intrahemispheric and interhemispheric functional connectivity of the resting and active brain. Methods: A total of 26 healthy humans were randomly divided into two groups that received either real cTBS or sham (control) over the left primary motor cortex. Surface electroencephalogram (EEG) was used to quantify the changes of neural oscillations after cTBS at rest and after a choice reaction time test. The cTBS-induced EEG oscillations were computed using spectral analysis of event-related coherence (ERCoh) of theta (4�7.5 Hz), low alpha (8�9.5 Hz), high alpha (10�12.5 Hz), low beta (13�19.5 Hz), and high beta (20�30 Hz) brain rhythms. Results: We observed a global decrease in functional connectivity of the brain in the cTBS group when compared to sham in the low beta brain rhythm at rest and high beta brain rhythm during the active state. In particular, EEG spectral analysis revealed that high-frequency beta, a cortically generated brain rhythm, was the most sensitive band that was modulated by cTBS. Conclusion: Overall, our findings suggest that cTBS, a TMS protocol that mimics the mechanism of long-term depression of synaptic plasticity, modulates motor network oscillations primarily at the cortical level and might interfere with cortical information coding. � Penerbit Universiti Sains Malaysia, 2015.en_US
dc.description.natureFinalen_US
dc.identifier.CODENMJMSA
dc.identifier.epage43
dc.identifier.issn1394195X
dc.identifier.scopus2-s2.0-84948980103
dc.identifier.spage35
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84948980103&partnerID=40&md5=0f97709cecc5ffe724e8d25c3b11a0c9
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/9482
dc.identifier.volume22
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherMalaysian Journal of Medical Sciencesen_US
dc.relation.ispartofMalaysian Journal of Medical Sciences
dc.sourceScopus
dc.subjectElectroencephalogramen_US
dc.subjectLong-term depressionen_US
dc.subjectMotor cortexen_US
dc.subjectNeuromodulationen_US
dc.subjectNeuroplasticityen_US
dc.titleTheta-burst transcranial magnetic stimulation alters the functional topography of the cortical motor networken_US
dc.title.alternativeMalays. J. Med. Sci.en_US
dc.typeArticleen_US
dspace.entity.typePublication

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