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Antimicrobial susceptibility of clinical isolates of Pseudomonas aeruginosa from a Malaysian Hospital

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dc.Chemicals/CASamikacin, 37517-28-5, 39831-55-5; cefepime, 88040-23-7; ceftazidime, 72558-82-8; ciprofloxacin, 85721-33-1; gentamicin, 1392-48-9, 1403-66-3, 1405-41-0; imipenem, 64221-86-9; meropenem, 96036-03-2
dc.citedby25
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.affiliationsHospital Kuala Lumpur
dc.contributor.affiliationsUKM Medical Molecular Biology Institute (UMBI)
dc.contributor.authorPathmanathan S.G.en_US
dc.contributor.authorSamat N.A.en_US
dc.contributor.authorMohamed R.en_US
dc.date.accessioned2024-05-28T08:39:51Z
dc.date.available2024-05-28T08:39:51Z
dc.date.issued2009
dc.description.abstractOngoing surveillance of Pseudomonas aeruginosa resistance against antimicrobial agents is fundamental to monitor trends in susceptibility patterns and to appropriately guide clinicians in choosing empirical or directed therapy. The in vitro activity level of eight antimicrobial drugs was assessed against 97 clinical isolates of P. aeruginosa collected consecutively for three months in 2007 from a Malaysian hospital. Antimicrobial susceptibility was determined using the E-test method in addition to the hospital's routine diagnostic testing by the disk diffusion method. Respiratory and wound swab isolates were the most frequently encountered isolates. The E-test and disk diffusion methods showed high concordance in determining the in vitro activity of the antimicrobial agents against the P. aeruginosa isolates. Piperacillin-tazobactam was the most active antimicrobial agent with 91.8% susceptibility, followed by the aminoglycosides (amikacin, 86.6% and gentamicin, 84.5%), the quinolone (ciprofloxacin, 83.5%) and the beta-lactams (cefepime, 80.4%, ceftazidime, 80.4%, imipenem, 79.4% and meropenem, 77.3%). Incidence of multidrug resistance was 19.6% (19 out of 97 isolates). Periodic antibiotic resistance surveillance is fundamental to monitor changes in susceptibility patterns in a hospital setting.en_US
dc.description.natureFinalen_US
dc.identifier.CODENMJMSA
dc.identifier.epage33
dc.identifier.issn1394195X
dc.identifier.issue2
dc.identifier.scopus2-s2.0-73149105313
dc.identifier.spage28
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-73149105313&partnerID=40&md5=2aa9cbdf7f6821308382e07d493afc17
dc.identifier.urihttp://www.mjms.usm.my/MJMSvol16no2.html
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/9251
dc.identifier.volume16
dc.languageEnglish
dc.language.isoen_USen_US
dc.relation.ispartofMalaysian Journal of Medical Sciencesen_US
dc.sourceScopus
dc.subjectAntibacterial agentsen_US
dc.subjectBacterial drug resistanceen_US
dc.subjectPseudomonas aeruginosaen_US
dc.titleAntimicrobial susceptibility of clinical isolates of Pseudomonas aeruginosa from a Malaysian Hospitalen_US
dc.title.alternativeMalays. J. Med. Sci.en_US
dc.typeArticleen_US
dspace.entity.typePublication

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