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NUB1 and FAT10 Proteins as Potential Novel Biomarkers in Cancer: A Translational Perspective

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dc.contributor.authorMaria Arshaden_US
dc.contributor.authorNazefah Abdul Hamiden_US
dc.contributor.authorMun Chiang Chanen_US
dc.contributor.authorFuad Ismailen_US
dc.contributor.authorGeok Chin Tanen_US
dc.contributor.authorFrancesco Pezzellaen_US
dc.contributor.authorTan Ka Liongen_US
dc.date.accessioned2024-05-27T14:35:17Z
dc.date.available2024-05-27T14:35:17Z
dc.date.issued2021
dc.date.submitted2021-10-27
dc.description.abstractCancer increases the global disease burden substantially, but it remains a challenge to manage it. The search for novel biomarkers is essential for risk assessment, diagnosis, prognosis, prediction of treatment response, and cancer monitoring. This paper examined NEDD8 ultimate buster-1 (NUB1) and F-adjacent transcript 10 (FAT10) proteins as novel biomarkers in cancer. This literature review is based on the search of the electronic database, PubMed. NUB1 is an interferon-inducible protein that mediates apoptotic and anti-proliferative actions in cancer, while FAT10 is a ubiquitin-like modifier that promotes cancer. The upregulated expression of both NUB1 and FAT10 has been observed in various cancers. NUB1 protein binds to FAT10 non-covalently to promote FAT10 degradation. An overexpressed FAT10 stimulates nuclear factor-kappa β, activates the inflammatory pathways, and induces the proliferation of cancer. The FAT10 protein interacts with the mitotic arrest deficient 2 protein, causing chromosomal instability and breast tumourigenesis. FAT10 binds to the proliferating cell nuclear antigen protein and inhibits the DNA damage repair response. In addition, FAT10 involves epithelial–mesenchymal transition, invasion, apoptosis, and multiplication in hepatocellular carcinoma. Our knowledge about them is still limited. There is a need to further develop NUB1 and FAT10 as novel biomarkers.en_US
dc.identifier.doi10.3390/cells10092176
dc.identifier.epage13
dc.identifier.issn2073-4409
dc.identifier.issue9
dc.identifier.other2224-10
dc.identifier.spage1
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/3334
dc.identifier.volume10
dc.language.isoenen_US
dc.publisherMDPI Multidisciplinary Digital Publishing Instituteen_US
dc.relation.ispartofCellsen_US
dc.subjectiomarker; cancer; FAT10; NUB1; NUB1Len_US
dc.titleNUB1 and FAT10 Proteins as Potential Novel Biomarkers in Cancer: A Translational Perspectiveen_US
dc.typeArticleen_US
dspace.entity.typePublication

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