Publication:
Preliminary Study on the Synthesis of Kojic Acid Monooleate Using Dual Enzymes System

dc.ConferencedateAPR 29-30, 2018
dc.ConferencelocationHo Chi Minh City, VIETNAM
dc.Conferencename4th International Conference on Green Design and Manufacture (IConGDM)
dc.contributor.authorRadzi, SMen_US
dc.contributor.authorZulhilmi, MNMen_US
dc.contributor.authorNoor, HMen_US
dc.contributor.authorRehan, MMen_US
dc.date.accessioned2024-05-29T02:51:38Z
dc.date.available2024-05-29T02:51:38Z
dc.date.issued2018
dc.description.abstractKojic acid is an organic acid that widely used in cosmetic, health care, food and chemical industries. However, kojic acid is not stable at high temperature, for long storage and it has low lipophilic properties. To overcome this problem, a study was conducted to improve its properties by enzymatic reaction. This study was focused on the synthesis of kojic acid monooleate from kojic acid and oleic acid using enzymatic catalysts at optimized conditions. This study was divided into three parts starting from enzymatic synthesis of kojic ester or specifically kojic acid monooleate (KAMO) by using a dual enzymes system that consisted of Novozym 435 and Lipozyme RM IM. Then, optimization of four variables such as screening of dual enzymes ratio, temperature, substrate molar ratio and the reaction time via conventional method of one parameter at-a-time approach and lastly verification of the product using Fourier Transfer Infrared (FTIR) spectroscopy. The optimum conditions for the enzymatic synthesis of KAMO were at the dual enzymes ratio (1: 1) of Novozym 435 and Lipozyme RMIM, temperature at 50 degrees C, the molar ratio of kojic acid and oleic acid were 4: 1 respectively and 24 hours of reaction time. The highest percentage conversion of KAMO achieved at the most optimum conditions was 13.22 %. Finally, kojic ester produced was verified by using FTIR proved the presence of ester bond (C=O) at 1743 cm(-1).
dc.identifier.doi10.1063/1.5066873
dc.identifier.issn0094-243X
dc.identifier.scopusWOS:000481681000232
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/11222
dc.identifier.volume2030
dc.languageEnglish
dc.language.isoen_US
dc.publisherAmer Inst Physicsen_US
dc.relation.ispartofGreen Design And Manufacture: Advanced And Emerging Applications
dc.sourceWeb Of Science (ISI)
dc.titlePreliminary Study on the Synthesis of Kojic Acid Monooleate Using Dual Enzymes System
dc.typeProceedings Paperen_US
dspace.entity.typePublication

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