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Anti-ulcerogenic effect of methanolic extracts from Enicosanthellum pulchrum (King) Heusden against ethanol-induced acute gastric lesion in animal models

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dc.contributor.authorNoraziah Binti Nordinen_US
dc.contributor.authorSuzy Munir Salamaen_US
dc.contributor.authorShahram Golbabapouren_US
dc.contributor.authorMaryam Hajrezaieen_US
dc.contributor.authorPouya Hassandarvishen_US
dc.contributor.authorBehnam Kamalidehghanen_US
dc.contributor.authorNazia Abdul Majiden_US
dc.contributor.authorNajihah Mohd Hashimen_US
dc.contributor.authorHanita Omaren_US
dc.contributor.authorMehran Fadaienasaben_US
dc.contributor.authorHamed Karimianen_US
dc.contributor.authorHairin Tahaen_US
dc.contributor.authorHapipah Mohd Alien_US
dc.contributor.authorMahmood Ameen Abdullaen_US
dc.date.accessioned2024-05-28T03:33:08Z
dc.date.available2024-05-28T03:33:08Z
dc.date.issued2014
dc.description.abstractA natural source of medicine, Enicosanthellum pulchrum is a tropical plant which belongs to the family Annonaceae. In this study, methanol extract from the leaves and stems of this species was evaluated for its gastroprotective potential against mucosal lesions induced by ethanol in rats. Seven groups of rats were assigned, groups 1 and 2 were given Tween 20 (10% v/v) orally. Group 3 was administered omeprazole 20 mg/kg (10% Tween 20) whilst the remaining groups received the leaf and stem extracts at doses of 150 and 300 mg/kg, respectively. After an additional hour, the rats in groups 2-7 received ethanol (95% v/v; 8 mL/kg) orally while group 1 received Tween 20 (10% v/v) instead. Rats were sacrificed after 1 h and their stomachs subjected to further studies. Macroscopically and histologically, group 2 rats showed extremely severe disruption of the gastric mucosa compared to rats pre-treated with the E. pulchrum extracts based on the ulcer index, where remarkable protection was noticed. Meanwhile, a significant percentage of inhibition was shown with the stem extract at 62% (150 mg/kg) and 65% (300 mg/kg), whilst the percentage with the leaf extract at doses of 150 and 300 mg/kg was 63% and 75%, respectively. An increase in mucus content, nitric oxide, glutathione, prostaglandin E2, superoxide dismutase, protein and catalase, and a decrease in malondialdehyde level compared to group 2 were also obtained. Furthermore, immunohistochemical staining of groups 4-7 exhibited down-regulation of Bax and up-regulation of Hsp70 proteins. The methanol extract from the leaves and the stems showed notable gastroprotective potential against ethanol.en_US
dc.identifier.citationNordin N, Salama SM, Golbabapour S, Hajrezaie M, Hassandarvish P, et al. (2014) Anti-Ulcerogenic Effect of Methanolic Extracts from Enicosanthellum pulchrum (King) Heusden against Ethanol-Induced Acute Gastric Lesion in Animal Models. PLOS ONE 9(11): e111925. https://doi.org/10.1371/journal.pone.0111925en_US
dc.identifier.doi10.1371/journal.pone.0111925
dc.identifier.epage13
dc.identifier.issn1932-6203
dc.identifier.issue11
dc.identifier.other2169-9
dc.identifier.spage1
dc.identifier.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0111925
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/4661
dc.identifier.volume9
dc.language.isoenen_US
dc.publisherPublic Library of Science (PLOS)en_US
dc.relation.ispartofPLoS Oneen_US
dc.titleAnti-ulcerogenic effect of methanolic extracts from Enicosanthellum pulchrum (King) Heusden against ethanol-induced acute gastric lesion in animal modelsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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