Publication:
Immunohistochemistry as a Detection Tool for Ion Channels Involved in Dental Pain Signaling

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dc.contributor.authorRosmaliza Ramlien_US
dc.contributor.authorSiti Norasikin Mohd Nafien_US
dc.contributor.authorNor Azura Ahmad Tarmidzien_US
dc.contributor.authorNurulezah Hasbullahen_US
dc.contributor.authorNurhafizah Ghanien_US
dc.date.accessioned2024-05-29T02:28:33Z
dc.date.available2024-05-29T02:28:33Z
dc.date.issued2022
dc.date.submitted2023-2-8
dc.descriptionVolume:34 Issue:3 (Pages 155-166)en_US
dc.description.abstractBackground: Despite advances in pain detection, diagnosis, and management, the prevalence of dental pain is still on the rise. Although dental pain is not directly related to fatal out-comes, the two most common types of dental pain—dental caries and dentin hypersensitivity—have a significant impact on an individual’s quality of life. Understanding the mechanism of the pain pathway is one of the crucial steps in providing better treatment for these patients. Ion channels are critical biomolecules that have been the subject of dental study owing to their roles in the trans-mission and transduction of external stimuli, as well as in the control and perception of pain. Numerous immunohistochemical (IHC) staining approaches have also been used to identify the many ion channels implicated in peripheral pain signaling in dental pulp. Highlight: This review highlights the critical steps in IHC and its role in the detection of ion channels involved in the dental pain signaling pathway. Conclusion: The key ion channels identified using IHC and whose functions have been widely researched in dental tissues are addressed in this review article.en_US
dc.identifier.doi10.1016/j.sdentj.2022.02.004
dc.identifier.epage166
dc.identifier.issn2524-1702
dc.identifier.issue3
dc.identifier.spage155
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1013905222000293?via%3Dihub
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85126017388&origin=resultslist&sort=plf-f&src=s&sid=3f1868111a303d5a05d758a34d75371e&sot=b&sdt=b&s=TITLE-ABS-KEY%28Immunohistochemistry+As+A+Detection+Tool+For+Ion+Channels+Involved+In+Dental+Pain+Signaling%29&sl=151&sessionSearchId=3f1868111a303d5a05d758a34d75371e
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/10767
dc.identifier.volume34
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.relation.ispartofThe Saudi Dental Journalen_US
dc.subjectImmunohistochemistry; Ion channel; Dental pain; Signaling pathway; Detection tool.en_US
dc.titleImmunohistochemistry as a Detection Tool for Ion Channels Involved in Dental Pain Signalingen_US
dc.typeArticleen_US
dspace.entity.typePublication

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