Cytotoxic Activity of Coumarin Derivatives and Their Complexes

Coumarin consists of a natural compounds group, which is found in different plants. Those Coumadin's, which are secluded from the plant, displayed that their compounds had a pasmolytic and hypotensive state, which has a vital role in plant biochemistry and physiology, by acting not only as antioxidants and enzyme inhibitors but as a precursor of toxic elements as well. Furthermore, these compounds have an essential role to play as plant growth hormones, growth regulators, respiratory control, and photosynthesis and as a defence mechanism against any kind of disease. They also play a role at various levels of cancer development since some of them have cytostatic characteristics, while others have cytotoxic effects on the organism. Thus shown, that the ancient correlation of plant coumarins with different animal and other species during evolution is the reason for the extensive spectrum in biochemical and pharmacological effects of these chemicals in biological arrangements. Metalo proteins, which are the hub of enzymatic process, which display an important role in biological arrangements. They discover the structure of active locations and play their part as biological redox assisters. Various cases proved that metal complexes of coumarin exhibited increased biological activities as compared to their ligands. As a result of their half-filled orbitals, transition metal display different oxidation states, and a diversity of coordination structures and ligand spheres.