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The role of microbial agents in the pathogenesis of inflammatory bowel disease

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dc.contributor.authorHuda-Faujan, N.en_US
dc.contributor.authorMustafa, Sen_US
dc.contributor.authorManaf, MYAen_US
dc.contributor.authorYee, LYen_US
dc.contributor.authorAbu Bakar, Fen_US
dc.date.accessioned2024-05-29T02:56:56Z
dc.date.available2024-05-29T02:56:56Z
dc.date.issued2007
dc.description.abstractInflammatory bowel disease (IBD) is a generic term that refers to Crohn's disease and ulcerative colitis. The precise aetiology of these diseases remains unknown. However, both are believed to result from the interaction of environmental factors, immune response and genetic factors. The impact of environmental factors such as smoking, diet, drug, geographical and social status, stress, microbial agents, intestinal permeability and appendectomy appear to be associated with IBD pathogenesis. Some varieties of these factors modify gene expression in susceptible individuals and modulate the effector function of the intestinal immune system. To understand the IBD pathogenesis, several studies have reported that luminal bacteria play an essential role in development of IBDs. Various bacterial pathogens have been incriminated but the results obtained have been conflicting. No specific pathogen has been identified as being causally associated with IBD. However, it is widely thought that, in IBD cases, individuals appear to lose the normal tolerance to commensal bacteria leading to an elevated inflammatory response. By contrast to healthy gut, the symbiotic relationship between the host and the commensal bacteria exposure leads to the down-regulation of inflammatory genes. Therefore, this brief review focuses on the microbial aetiology of IBD. (c) 2007 Wolters Kluwer Health.en_US
dc.identifier.epage53
dc.identifier.issn0954-139X
dc.identifier.issue3
dc.identifier.scopusWOS:000251946700002
dc.identifier.spage47
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/11612
dc.identifier.volume18
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofReviews In Medical Microbiologyen_US
dc.sourceWeb Of Science (ISI)
dc.subjectCrohn's diseaseen_US
dc.subjectinflammatory bowel disease (IBD)en_US
dc.subjectmicrobial agenten_US
dc.subjectsulphate reducing bacteria (SRB)en_US
dc.subjectulcerative collitisen_US
dc.titleThe role of microbial agents in the pathogenesis of inflammatory bowel diseaseen_US
dc.typeArticleen_US
dspace.entity.typePublication

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