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Phoenix Dactylifera (Date Fruits) Administration To Animal Models Of Neurological Diseases: A Systematic Review Of Health Benefits

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dc.contributor.authorNurlaily, Aen_US
dc.contributor.authorNoraini, Sen_US
dc.contributor.authorSaid, SNen_US
dc.contributor.authorJayachandran, Ren_US
dc.contributor.authorAzlina, Men_US
dc.contributor.authorOthman, Aen_US
dc.contributor.authorShamaan, NAen_US
dc.contributor.authorNoh, NAen_US
dc.date.accessioned2024-05-29T02:50:40Z
dc.date.available2024-05-29T02:50:40Z
dc.date.issued2016
dc.description.abstractA systematic review of literature was conducted to examine the effects of date fruit (Phoenix dactylifera) interventions aimed at alleviating neurological diseases in animal models. Searches were conducted on electronic databases including EMBASE, PubMed, Scopus and Web of Science as well as hand searching. Retrieved studies represented a variety of intervention approaches (types of extraction, parts of plant used) with animal models of ischemic stroke, Alzheimer's disease, and substance -induced brain damage. Phoenix dactylifera interventions were associated with reduced degeneration of neurons, reduced oxidative stress markers, improved antioxidant status and neuronal histological changes in ischemic stroke.and brain damage when compared to the control. Phoenix dactylifera was also found to reduce oxidative stress level and improve endogenous antioxidant status, lower plasma level of beta-amyloid and neuroinflammatory cytokine, improved neurobehavioral deficits and cognitive performances in the Alzheimer's group. This review suggests that there is an association between Phoenix dactylifera and improvement of neurological disease markers in animal models of neurological diseases. The effects of Phoenix dactylifera by reducing oxidative stress level and improving antioxidant status in neurological diseases render it as a potential neuroprotective agent. However, further studies are needed to confirm the role of Phoenix dactylifera in conferring neuroprotective activity.en_US
dc.identifier.citationNurlaily, A., Noraini, S., Said, S. N., Jayachandran, R., Azlina, M., Othman, A., Shamaan, N. A., & Noh, N. A. (2016). Phoenix dactylifera (date fruits) administration to animal models of neurological diseases: A systematic review of health benefits. Current Topics in Nutraceutical Research, 14(3), 181+. https://link.gale.com/apps/doc/A479943048/HRCA?u=anon~f7a77720&sid=googleScholar&xid=0c09994den_US
dc.identifier.epage189
dc.identifier.issn1540-7535
dc.identifier.issue3
dc.identifier.scopusWOS:000384942900001
dc.identifier.spage181
dc.identifier.urihttps://go.gale.com/ps/i.do?id=GALE%7CA479943048&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=15407535&p=HRCA&sw=w&userGroupName=anon%7Ef7a77720
dc.identifier.urihttps://web.s.ebscohost.com/ehost/detail/detail?vid=0&sid=cdbc3494-c0b4-4a70-8740-adff6c3953e8%40redis&bdata=JnNpdGU9ZWhvc3QtbGl2ZSZzY29wZT1zaXRl#db=a9h&AN=119800952
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/11095
dc.identifier.volume14
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherNew Century Health Publishers, Llcen_US
dc.relation.ispartofCurrent Topics In Nutraceutical Researchen_US
dc.sourceWeb Of Science (ISI)
dc.subjectAntioxidant;en_US
dc.subjectBrain diseases;en_US
dc.subjectDate fruits;en_US
dc.subjectNeuroprotection;en_US
dc.subjectOxidative stressen_US
dc.titlePhoenix Dactylifera (Date Fruits) Administration To Animal Models Of Neurological Diseases: A Systematic Review Of Health Benefitsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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