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Flavonoids as Natural Anti-Inflammatory Agents Targeting Nuclear Factor-Kappa B (NF kappa B) Signaling in Cardiovascular Diseases: A Mini Review

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dc.contributor.authorKer Woon Choyen_US
dc.contributor.authorDharmani Muruganen_US
dc.contributor.authorXin-Fang Leongen_US
dc.contributor.authorRazif Abasen_US
dc.contributor.authorAspalilah Aliasen_US
dc.contributor.authorMohd Rais Mustafaen_US
dc.date.accessioned2024-05-29T03:25:20Z
dc.date.available2024-05-29T03:25:20Z
dc.date.issued2019
dc.description.abstractCardiovascular diseases (CVDs) such as angina, hypertension, myocardial ischemia, and heart failure are the leading causes of morbidity and mortality worldwide. One of the major transcription factors widely associated with CVDs is nuclear factor-kappa B (NF kappa B). NF kappa B activation initiates the canonical and non-conical pathways that promotes activation of transcription factors leading to inflammation, such as leukocyte adhesion molecules, cytokines, and chemokines. Flavonoids are bioactive polyphenolic compounds found abundantly in various fruits, vegetables, beverages (tea, coffee), nuts, and cereal products with cardiovascular protective properties. Flavonoids can be classified into six subgroups based on their chemical structures: flavanones, flavones, flavonols, flavan-3-ols, isoflavones, and anthocyanidins. As NF kappa B inhibitors, these flavonoids may modulate the expression of pro-inflammatory genes leading to the attenuation of the inflammatory responses underlying various cardiovascular pathology. This review presents an update on the anti-inflammatory actions of flavonoids via inhibition of NF kappa B mechanism supporting the therapeutic potential of these natural compounds in various CVDs.en_US
dc.identifier.doi10.3389/fphar.2019.01295
dc.identifier.issn1663-9812
dc.identifier.scopusWOS:000497404300001
dc.identifier.urihttps://www.frontiersin.org/articles/10.3389/fphar.2019.01295/full
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/11941
dc.identifier.volume10
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers In Pharmacologyen_US
dc.sourceWeb Of Science (ISI)
dc.subjectflavonoidsen_US
dc.subjectnuclear factor-kappa B signallingen_US
dc.subjectanti-inflammatoryen_US
dc.subjectcardiovascular diseasesen_US
dc.subjectnatural compoundsen_US
dc.titleFlavonoids as Natural Anti-Inflammatory Agents Targeting Nuclear Factor-Kappa B (NF kappa B) Signaling in Cardiovascular Diseases: A Mini Reviewen_US
dc.typeArticleen_US
dspace.entity.typePublication

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