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Liver Allograft Biopsies: Experience in Hospital Selayang

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dc.contributor.authorNoor Afi dah MSen_US
dc.contributor.authorNoor Laili MMen_US
dc.contributor.authorNik Malihan NSen_US
dc.contributor.authorNur Syahrina Rahimen_US
dc.contributor.authorNorfadzilah MYen_US
dc.date.accessioned2024-05-28T06:37:43Z
dc.date.available2024-05-28T06:37:43Z
dc.date.issued2011
dc.descriptionPosteren_US
dc.description.abstractIntroduction: Liver biopsies are important to document any allograft rejection in liver transplantation. As one of the main centres providing liver transplant services, we are fortunate to experience dealing with liver allograft biopsies. Here, we briefl y describe our experience over a 7-year period. Materials and Methods: All reports of liver allograft biopsies performed from January 2004 to December 2010 in Hospital Selayang along with the relevant clinicopathological data were retrieved from the Department of Pathology archives using Cerner Pathnet Application. Results: There were 29 biopsies done from 18 patients aged between 19 months to 47 years old. Eleven of them were from males and 7 were female patients. There were 10 Malays, 5 were Chinese and 3 were Indians. Biliary atresia, Tyrosinaemia, Alagille’s syndrome and fulminant liver failure were some of the earlier indications or aetiologies for the liver transplantation. Most of them showed abnormal liver enzymes prior to allograft biopsy. The biopsies were evaluated using Banff scheme for liver allograft rejection. Ten (34.5%) of the cases showed acute rejection, 2 of the cases was indeterminate and another 2 cases showed chronic rejection. Fourteen (48.3%) of the cases showed no evidence of rejection. Drug induced injury, chronic biliary outfl ow obstruction, vanishing bile duct syndrome and chronic hepatitis were among the histopathological changes found in the allograft biopsies of these 14 cases. Conclusion: Liver biopsy is useful to evaluate graft dysfunction and to confi rm clinically suspected rejection. Adequate interpretation is dependent on adequacy of sampling, knowledge of differential diagnoses, clinical aspects of transplant hepatology and also close interaction with the clinical team.en_US
dc.identifier.citationMS, Noor & MM, Noor & NS, NikMalihan & Rahim, Nur & MY, NorFadzilah. (2011). Liver Allograft Biopsies: Experience in Hospital Selayang. The Malaysian journal of pathology. 33. 142.en_US
dc.identifier.epage142
dc.identifier.issn0126-8635
dc.identifier.issue2
dc.identifier.spage142
dc.identifier.urihttp://www.mjpath.org.my/2015/v37n2/abstracts.pdf
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/7404
dc.identifier.volume33
dc.language.isoenen_US
dc.publisherCollege of Pathologists, Academy of Medicine Malaysiaen_US
dc.relation.conferenceConference: The 10th Annual Scientifi c Meeting of the College of Pathologists, Academy of Medicine MalaysiaAt: Meritus Pelangi Beach Resort and Spa, Langkawi, Kedah, June 2011en_US
dc.relation.ispartofThe Malaysian Journal of Pathologyen_US
dc.subjectliver allograft biopsyen_US
dc.subjectliver transplanten_US
dc.subjectrejectionen_US
dc.titleLiver Allograft Biopsies: Experience in Hospital Selayangen_US
dc.typeArticleen_US
dspace.entity.typePublication

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