Publication:
Detection Of Homozygous Haemoglobin Constant Spring By Capillary Electrophoresis Method

Simple item page
dc.contributor.authorRaja-Zahratul Azma,en_US
dc.contributor.authorKhamisah M-Gaus ,en_US
dc.contributor.authorSuria A-Aziz ,en_US
dc.contributor.authorHafiza Alauddin ,en_US
dc.contributor.authorAzlin Ithnin ,en_US
dc.contributor.authorNoor-Farisah Razak ,en_US
dc.contributor.authorNor-Hidayati Sardi ,en_US
dc.contributor.authorMalisa Mohd-Yusoff ,en_US
dc.contributor.authorZarina A-Latiff ,en_US
dc.contributor.authorHamidah Alias ,en_US
dc.contributor.authorEndom Ismail ,en_US
dc.contributor.authorDanny Koh-Xuan-Rongen_US
dc.contributor.authorAinoon Othmanen_US
dc.date.accessioned2024-05-27T14:48:05Z
dc.date.available2024-05-27T14:48:05Z
dc.date.issued2016
dc.description.abstractIntroduction: Hemoglobin Constant Spring (HbCS) is often missed due to almost normal red cells indices and is present at a low level in peripheral blood. However, analysis of blood samples using capillary electrophoresis (CE) is able to differentiate between heterozygous and homozygous state of HbCS. Methods: An eight-year-old Malay girl presented with severe anaemia and hepatosplenomegaly following a viral infection. The diagnosis of homozygous HbCS was made from Hb analysis by CE which showed a small peak (5.3%) at Hb CS zone. His brother had similar CE findings while both of her father and mother showed much smaller peaks (0.7% and 0.4% respectively) at similar zone which were consistent with heterozygous HbCS. All findings were confirmed by few molecular analysis techniques. Conclusion: This case highlights the importance of detection of homozygous HbCS by CE. CE is useful as a fast screening method for detection of HbCS in hematology laboratory where molecular analysis is not available and patient with homozygous HbCS has higher risk to develope acute hemolysis when having infection. Keywords: Capillary electrophoresis, Hb Constant Spring, Homozygous state.en_US
dc.identifier.citationARC Journal of Hematology Volume 1, Issue 1, 2016, PP 28-32 www.arcjournals.orgen_US
dc.identifier.epage32
dc.identifier.issn0-0
dc.identifier.issue1
dc.identifier.other1515-42
dc.identifier.spage28
dc.identifier.urihttps://www.arcjournals.org/pdfs/ajh/v1-i1/6.pdf
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/3791
dc.identifier.volume1
dc.language.isoenen_US
dc.publisherARC Publicationsen_US
dc.relation.ispartofARC Journal of Haematologyen_US
dc.subjectCapillary electrophoresis,en_US
dc.subjectHb Constant Spring,en_US
dc.subjectHomozygous stateen_US
dc.titleDetection Of Homozygous Haemoglobin Constant Spring By Capillary Electrophoresis Methoden_US
dc.typeArticleen_US
dspace.entity.typePublication

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Detection Of Homozygous Haemoglobin Constant Spring By Capillary Electrophoresis Method.pdf
Size:
405.11 KB
Format:
Adobe Portable Document Format
Description:
Detection Of Homozygous Haemoglobin Constant Spring By Capillary Electrophoresis Method
Download

Collections

Other Publications