Publication: Pseuduvarines A And B,two New Cytotoxic Dioxoaporphine Alkaloids From Pseuduvaria Rugosa
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Date
2011
Journal Title
Journal ISSN
Volume Title
Publisher
Pharmaceutical Society of Japan
Abstract
Pseuduvarines A (1) and B (2), two new dioxoaporphine alkaloids with an amino moiety, were isolated from the stem bark of Pseuduvaria rugosa and their structures were elucidated by combination of 2D-NMR spectroscopic analysis. Pseuduvarines A (1) and B (2) showed cytotoxicity against MCF7, HepG2, and HL-60 (1: IC50, 0.9, 21.7, and >50.0 μM, respectively, 2: IC50 >50.0, 15.7, and 12.4 μM, respectively).
Description
Volume 59 Issue 7
Keywords
pseuduvarine A; pseuduvarine B; dioxoaporphine; Pseuduvaria rugosa; cytotoxic activity