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Aporphine Alkaloids from the Leaves of Phoebe grandis (Nees) Mer. (Lauraceae) and Their Cytotoxic and Antibacterial Activities

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dc.contributor.authorHanita Omaren_US
dc.contributor.authorNajihah Mohd. Hashimen_US
dc.contributor.authorAsdren Zajmien_US
dc.contributor.authorNoraziah Nordinen_US
dc.contributor.authorSiddiq Ibrahim Abdelwahaben_US
dc.contributor.authorAinnul Hamidah Syahadah Azizanen_US
dc.contributor.authorA. Hamid A. Hadien_US
dc.contributor.authorHapipah Mohd Alien_US
dc.date.accessioned2024-05-28T05:48:16Z
dc.date.available2024-05-28T05:48:16Z
dc.date.issued2013
dc.descriptionVolume 18 Issue 8en_US
dc.description.abstractThe oxoaporphine alkaloid lysicamine (1), and three proaporphine alkaloids, litsericinone (2), 8,9,11,12-tetrahydromecambrine (3) and hexahydromecambrine A (4) were isolated from the leaves of Phoebe grandis (Nees) Merr. (Lauraceae). Compounds 2 and 3 were first time isolated as new naturally occurring compounds from plants. The NMR data for the compounds 2–4 have never been reported so far. Compounds 1 and 2 showed significant cytotoxic activity against a MCF7 (human estrogen receptor (ER+) positive breast cancer) cell line with IC50 values of 26 and 60 µg/mL, respectively. Furthermore, in vitro cytotoxic activity against HepG2 (human liver cancer) cell line was evaluated for compounds 1–4 with IC50 values of 27, 14, 81 and 20 µg/mL, respectively. Lysicamine (1) displayed strong antibacterial activity against Bacillus subtilis (B145), Staphylococcus aureus (S1434) and Staphylococus epidermidis (a clinically isolated strain) with inhibition zones of 15.50 ± 0.57, 13.33 ± 0.57 and 12.00 ± 0.00 mm, respectively. However, none of the tested pathogenic bacteria were susceptible towards compounds 2 and 3en_US
dc.identifier.doi10.3390/molecules18088994
dc.identifier.epage9009
dc.identifier.issn1420-3049
dc.identifier.issue8
dc.identifier.spage8994
dc.identifier.urihttps://www.mdpi.com/1420-3049/18/8/8994
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/6547
dc.identifier.volume18
dc.language.isoen_USen_US
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)en_US
dc.relation.ispartofMoleculesen_US
dc.subjectPhoebe grandis; Lauraceae; aporphine alkaloid; cytotoxic; antibacterialen_US
dc.titleAporphine Alkaloids from the Leaves of Phoebe grandis (Nees) Mer. (Lauraceae) and Their Cytotoxic and Antibacterial Activitiesen_US
dc.typeArticleen_US
dspace.entity.typePublication

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