Publication:
Therapeutic effect of Ipomoea Batatas extracts on induced psoriasis in mice

Simple item page
dc.contributor.authorAnuar Bin Sanien_US
dc.contributor.authorWan Omar Abdullahen_US
dc.contributor.authorMohamed Adel Rahimen_US
dc.contributor.authorNgah Zasmy Unyahen_US
dc.contributor.authorNur Syahrina Rahimen_US
dc.contributor.authorSazlina Kamaralzamanen_US
dc.date.accessioned2024-05-28T05:45:17Z
dc.date.available2024-05-28T05:45:17Z
dc.date.issued2015
dc.descriptionThe 2015 Annual Scientific Meeting of the College of Pathologists, Academy of Medicine Malaysia & 40th Anniversary Celebration of the Pathology Advocates was held at Berjaya Time Square Hotel, Kuala Lumpur from 13-14 June 2015.en_US
dc.description.abstractIntroduction: Psoriasis is a non-curable, T-cell mediated autoimmune chronic skin disease with a prevalence of 5% in Malaysia (cf. world average of 2%). Treatment options are essentially symptomatic dominated by oral or topical steroids and in severe cases require anti-cancer drug such as methotrexate or anti T-cells drug likes cyclosporine. Sweet potato (Ipomoea batatas) leaves (SPL), a common edible plant in Malaysia has been anecdotally reported by a number of psoriatic patients to be effective in inducing remission. Materials and methods: Psoriasifom lesions were induced in 15 male BALB/c mice using imiquimoid for 21 days and divided into 3 equal groups. One group was designated as control and the other two groups were subjected to topical application of aqueous SPL extract and lipophilic SPL extract respectively. Modified psoriatic Area and Severity Index (PASI) score, histological changes and intracellular cytokines of TNF-? and IFN-? were compared between the groups for pre-induction, post induction and post treatment. Result: Both groups subjected to topical SPL extracts showed significant improvement compared to control group with slight therapeutic superiority shown by the lipophilic extract in all parameters. No toxicity effect evidenced by histological examination noted. Discussion: Synergistic effect of bioactive compounds within the SPL extracts especially by the lipophilic components showed promising potential to be a steroid-sparing anti-psoriactic medication. Further confirmation of its potential using psoriatic patients should be undertaken to assess its true potential.en_US
dc.identifier.citationSani, Anuar & Abdullah, Wan & Rahim, Mohamed & Unyah, Ngah & Rahim, Nur & Kamaralzaman, Sazlina. (2015). Therapeutic effect of Ipomoea Batatas extracts on induced psoriasis in mice.en_US
dc.identifier.epage209
dc.identifier.issn0126-8635
dc.identifier.issue2
dc.identifier.spage209
dc.identifier.urihttp://www.mjpath.org.my/2015/v37n2/abstracts.pdf
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/6352
dc.identifier.volume37
dc.language.isoenen_US
dc.publisherCollege of Pathologists, Academy of Medicine Malaysiaen_US
dc.relation.ispartofThe Malaysian journal of Pathologyen_US
dc.titleTherapeutic effect of Ipomoea Batatas extracts on induced psoriasis in miceen_US
dc.typeArticleen_US
dspace.entity.typePublication

Files

Collections

Other Publications