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Synthesis and biological evaluation of 6-hydroxy-4-methyl-5,7-(bis-p-chlorophenylazo) coumarin

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dc.citedby1
dc.contributor.affiliationsFaculty of Science and Technology
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.authorIbrahim D.M.en_US
dc.contributor.authorJumal J.en_US
dc.contributor.authorHarun F.W.en_US
dc.date.accessioned2024-05-28T08:24:55Z
dc.date.available2024-05-28T08:24:55Z
dc.date.issued2015
dc.description.abstract6-hydroxy-4-methyl-5,7-(bis-p-chlorophenylazo)coumarin has been synthesized and characterized by CHN elemental analysis, FTIR,1H-NMR-spectroscopy and mass-spectral data. Cytotoxic screening by MTT assay was carried out on the compound against breast cancer cells. The overall results from preliminary screening program revealed that the cell proliferation was highly inhibited by 6-hydroxy-4-methyl-5,7-(bis-p-chlorophenylazo) coumarin with the value of 2.81%, at concentration of 30 ?g mL?1 compared with the untreated control cells and also possessed a good chelating activity with IC50 value 1.87 ?g mL?1. It is suggested that the cytotoxic activity is affected by hydroxyl and halogen groups as these groups have high electron affinity and high electronegativity. � 2016 Dalal M. Ibrahim, Juliana Jumal and Farah Wahida Harun.
dc.description.natureFinalen_US
dc.identifier.ArtNo1.6
dc.identifier.doi10.3844/ajassp.2016.1.6
dc.identifier.epage6
dc.identifier.issn15469239
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85000642931
dc.identifier.spage1
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85000642931&doi=10.3844%2fajassp.2016.1.6&partnerID=40&md5=108bf7080f798d920661b46a09d5917f
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/8582
dc.identifier.volume13
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherScience Publicationsen_US
dc.relation.ispartofAmerican Journal of Applied Sciences
dc.sourceScopus
dc.subjectBis-Coumarinsen_US
dc.subjectBreast canceren_US
dc.subjectCytotoxic activityen_US
dc.titleSynthesis and biological evaluation of 6-hydroxy-4-methyl-5,7-(bis-p-chlorophenylazo) coumarinen_US
dc.title.alternativeAm. J. Appl. Sci.en_US
dc.typeArticleen_US
dspace.entity.typePublication

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