Publication:
Association Of Serum Vitamin D Level And Vitamin D Receptor Expression Among Newly Diagnosed Breast Cancer

Simple item page
dc.contributor.authorHani Ajrina Zulkefleeen_US
dc.contributor.authorTuan Salwani Tuan Ismailen_US
dc.contributor.authorTengku Ahmad Damitri Al-Astani Tengku Dinen_US
dc.contributor.authorMaya Mazuwin Yahyaen_US
dc.contributor.authorWan Faiziah Wan Abdul Rahmanen_US
dc.date.accessioned2024-05-27T14:49:06Z
dc.date.available2024-05-27T14:49:06Z
dc.date.issued2021
dc.date.submitted2021-12-31
dc.description.abstractThere is a mushrooming interest in the anti-carcinogenic property of vitamin D. However, many researches reported a conflicting result in the association of vitamin D levels to certain types of cancer. This study was designed to assess the association between vitamin D and vitamin D receptor (VDR) expression with breast cancer. This case-control study, carried out at Hospital Universiti Sains Malaysia, Kelantan, involved 69 newly diagnosed breast cancer patients and 73 healthy volunteers. Serum 25(OH)D was taken and compared between 2 groups. VDR expression in patients’ breast tissue samples was determined by immunohistochemical staining method using anti-VDR antibody. 85.5% of breast cancer patients and 97.3% of healthy control were vitamin D insufficient with a mean (SD) of 13.36 (6.96) ng/mL and 13.05 (3.71) ng/mL, respectively, and the difference was not statistically significant. VDR expression showed cytoplasmic positivity in 75.4% of breast cancer tissue, followed by both cytoplasmic and nuclear positivity in 21.5% and complete absence in 3%. There was no significant association between VDR expression and hormone receptor status. In conclusion, there was a high prevalence of vitamin D deficiency among breast cancer and healthy volunteers in our study. There was no significant association between breast cancer and vitamin D. The VDR expression in breast cancer cells showed high cytoplasmic localization.en_US
dc.identifier.doi10.17576/jsm-2021-5011-16
dc.identifier.epage3332
dc.identifier.issn0126-6039
dc.identifier.issue11
dc.identifier.other2054-1
dc.identifier.spage3321
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/3815
dc.identifier.volume50
dc.language.isoenen_US
dc.publisherPenerbit Universiti Kebangsaan Malaysiaen_US
dc.relation.ispartofSains Malaysianaen_US
dc.subjectBreast cancer; prognosis; risk; vitamin D; vitamin D receptor expressionen_US
dc.titleAssociation Of Serum Vitamin D Level And Vitamin D Receptor Expression Among Newly Diagnosed Breast Canceren_US
dc.title.alternativeHubungan antara Tahap Serum Vitamin D dan Pengekspresan Reseptor Vitamin D dalam Kalangan Pesakit Kanser Payudara Baharu Didiagnosen_US
dc.typeArticleen_US
dspace.entity.typePublication

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
256. Association Of Serum Vitamin D Level And Vitamin D Receptor Expression Among Newly Diagnosed Breast Cancer.pdf
Size:
2.35 MB
Format:
Adobe Portable Document Format
Download

Collections

Other Publications