Publication:
Potential Health And Economic Impacts Of Dexamethasone Treatment For Patients With Covid-19

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cris.lastimport.scopus2025-11-14T15:55:14Z
cris.lastimport.wos2025-11-14T15:42:21Z
dc.contributor.authorRicardo Águasen_US
dc.contributor.authorAdam Mahdien_US
dc.contributor.authorRima Shrettaen_US
dc.contributor.authorPeter Horbyen_US
dc.contributor.authorMartin Landrayen_US
dc.contributor.authorLisa Whiteen_US
dc.contributor.authorAmirah Azzerien_US
dc.date.accessioned2024-05-27T14:34:23Z
dc.date.available2024-05-27T14:34:23Z
dc.date.issued2021
dc.date.submitted2022-1-3
dc.description.abstractDexamethasone can reduce mortality in hospitalised COVID-19 patients needing oxygen and ventilation by 18% and 36%, respectively. Here, we estimate the potential number of lives saved and life years gained if this treatment were to be rolled out in the UK and globally, as well as the cost-effectiveness of implementing this intervention. Assuming SARS-CoV-2 exposure levels of 5% to 15%, we estimate that, for the UK, approximately 12,000 (4,250 - 27,000) lives could be saved between July and December 2020. Assuming that dexamethasone has a similar effect size in settings where access to oxygen therapies is limited, this would translate into approximately 650,000 (240,000 - 1,400,000) lives saved globally over the same time period. If dexamethasone acts differently in these settings, the impact could be less than half of this value. To estimate the full potential of dexamethasone in the global fight against COVID-19, it is essential to perform clinical research in settings with limited access to oxygen and/or ventilators, for example in low- and middle-income countries.en_US
dc.identifier.citationÁguas, R., Mahdi, A., Shretta, R. et al. Potential health and economic impacts of dexamethasone treatment for patients with COVID-19. Nat Commun 12, 915 (2021). https://doi.org/10.1038/s41467-021-21134-2en_US
dc.identifier.doi10.1038/s41467-021-21134-2
dc.identifier.epage8
dc.identifier.issn2041-1723
dc.identifier.issue915
dc.identifier.other2446-11
dc.identifier.spage1
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/3181
dc.identifier.volume12
dc.language.isoenen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofNature Communicationsen_US
dc.titlePotential Health And Economic Impacts Of Dexamethasone Treatment For Patients With Covid-19en_US
dc.typeArticleen_US
dspace.entity.typePublication

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