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Synthesis and cytotoxic activity of 6-hydroxy-4-methyl-5,7-(bis-phenylazo) coumarin with divalent transition metal ions

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dc.citedby2
dc.contributor.affiliationsFaculty of Science and Technology
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.authorIbrahim D.M.en_US
dc.contributor.authorJumal J.en_US
dc.contributor.authorHarun F.W.en_US
dc.date.accessioned2024-05-28T08:37:17Z
dc.date.available2024-05-28T08:37:17Z
dc.date.issued2016
dc.description.abstractBackground/Objectives: One of the severe disease intimidating human health and continues to be a main health problem worldwide is cancer. Hence, discovering new compounds with powerful anticancer activity is of extreme important. The main objective of this paper is the synthesize 6-hydroxy-4-methyl-5,7-(bis-phenylazo) coumarin and its complexes and evaluate the cytotoxic activity of the ligand and complexes against breast cancer cells. Methods/Statistical Analysis: A novel compounds of 6-hydroxy-4-methyl-5,7-(bis-phenylazo) coumarin have been synthesized by 6-hydroxy-4-methylcoumarin. The complexation of nickel (II), copper (II) and cobalt (II) using this ligand gave salt type complexes with the formula of M(C22H15O3N4) the compounds were characterized by microelemental analysis, infra-red, nuclear magnetic resonance spectroscopic techniques and molar conductivity. Cytotoxic activity for the ligand and the complexes were evaluated against breast cancer cells by using MTT assay and the absorbance at 570 nm was measured by ELISA reader. Findings: The CHN analysis of the compounds are in good agreement with the calculated values and the spectroscopic analysis of the complexes indicated that the ligand coordinated to the metal centres as polydentate ligand in bisazocoumarin and form a distorted octahedral arrangement around nickel (II), copper (II) and cobalt (II) centres. The molar conductivity of the divalent metal ions complexes was small which directly supports the fact that all of the investigated complexes are non ionic. The overall results of cells MCF7 breast cancer revealed of cell proliferation was much more highly inhibited by the ligand and complexes Cu, Co and Ni with cell viability 5.21%, 17.36%, 46.20% and 74.43%, respectively at a concentration of 30 mg/ml compared to untreated control cells and IC50 values of the ligands and complexes of Cu, Co and Ni were 1.87, 1.87, 30 and >30 g/ml, respectively. Improvements: Lastly, some suggestions were presented to use these compounds in vivo should be assessed to obtain worthy anticancer drugs.
dc.description.natureFinalen_US
dc.identifier.ArtNo61431
dc.identifier.doi10.17485/ijst/2016/v9i37/61431
dc.identifier.issn9746846
dc.identifier.issue37
dc.identifier.scopus2-s2.0-85010805013
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85010805013&doi=10.17485%2fijst%2f2016%2fv9i37%2f61431&partnerID=40&md5=78f374709d1f1f0da9d2d7aedba30c9c
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/9181
dc.identifier.volume9
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherIndian Society for Education and Environmenten_US
dc.relation.ispartofIndian Journal of Science and Technology
dc.sourceScopus
dc.subjectBis-Azocoumarinen_US
dc.subjectBreast Cancer MCF7en_US
dc.subjectComplexes of Nickelen_US
dc.subjectCopper and Cobalten_US
dc.subjectMTT Assayen_US
dc.titleSynthesis and cytotoxic activity of 6-hydroxy-4-methyl-5,7-(bis-phenylazo) coumarin with divalent transition metal ionsen_US
dc.title.alternativeIndian J. Sci. Technol.en_US
dc.typeArticleen_US
dspace.entity.typePublication

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