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Endometrial Heparin-binding Epidermal Growth Factor Gene Expression And Hormone Level Changes In Implantation\r\nWindow Of Obese Women With Polycystic Ovarian Syndrome

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dc.contributor.authorZulazmi Sutajien_US
dc.contributor.authorMuhammad Azrai Abuen_US
dc.contributor.authorNurainie Sayuttien_US
dc.contributor.authorMarjanu Hikmah Eliasen_US
dc.contributor.authorMohd Faizal Ahmaden_US
dc.contributor.authorAbdul Ghani Nur Azurahen_US
dc.contributor.authorKah Teik Chewen_US
dc.contributor.authorAbdul Kadir Abdul Karimen_US
dc.contributor.authorNor Haslinda Abd Azizen_US
dc.contributor.authorMohd Helmy Mokhtaren_US
dc.contributor.authorReena Rahayu Md Zinen_US
dc.contributor.authorZeti Azura Mohamed Husseinen_US
dc.date.accessioned2024-05-28T06:07:15Z
dc.date.available2024-05-28T06:07:15Z
dc.date.issued2023
dc.date.submitted2023-1-31
dc.descriptionVolume 11 Issue 2 Page (1-9)en_US
dc.description.abstractIntroduction: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder amongst reproductive-age women, and 61% to 76% of women with PCOS are obese. Obese women with PCOS are usually burdened with infertility problems due to implantation failure. Thus, progesterone treatment is usually used to improve implantation rates. Although Hb-EGF expression is actively involved in endometrial receptivity and implantation, the data on heparin-binding epidermal growth factor (Hb-EGF) expression following progesterone therapy in obese women with PCOS are still lacking. Objective: To investigate the changes in serum follicle-stimulating hormone (FSH), luteinising hormone (LH), dehydroepiandrosterone sulphate (DHEA), progesterone and oestradiol levels and Hb-EGF expression in obese women with PCOS during the implantation window following progesterone therapy. Method: A total of 40 participants aged 18–40 years old were recruited following the provision of written consent. The participants were divided into the obese PCOS, normal-weight PCOS, obese fertile and normal-weight fertile groups. First blood collection was done before ovulation. Then, daily oral micronised progesterone (Utrogestan 200 mg) was given to the PCOS group for 10 days. The treatment was followed by a second blood collection and endometrial tissue sampling by using a Pipelle de Cornier catheter. In the fertile group, ovulation was confirmed by using ultrasound, and a second blood sample was collected on days 7 to 9 postovulation. The serum levels of FSH, LH, DHEA, progesterone and oestradiol were measured in all participants. Wilcoxon signed-rank test was used to compare FSH, LH, DHEA, progesterone and oestradiol levels during pre- and postovulation. Mann–Whitney test was performed to compare FSH, LH, DHEA, progesterone and oestradiol levels between two groups: (1) the PCOS group and the fertile group, (2) the obese PCOS group and the non-obese PCOS group and (3) the obese group and the non-obese fertile group. Result: Serum FSH levels were lower in obese women in their follicular phase than in women with normal weight regardless of their PCOS status, whereas serum LH/FSH ratios and DHEA levels were higher in women with PCOS than in women without PCOS. However, endometrial Hb-EGF expression was lower in the obese PCOS group than in the normal-weight PCOS group. Conclusions: Different patterns of hormonal levels and Hb-EGF expression levels were seen between the studied groups. However, further in vitro and in vivo studies are needed to investigate the mechanism underlying the changes in FSH, LH/FSH ratio, DHEA and Hb-EGF expression in PCOS after progesterone treatment.en_US
dc.identifier.citationSutaji, Z.; Abu, M.A.; Sayutti, N.; Elias, M.H.; Ahmad, M.F.; Nur Azurah, A.G.; Chew, K.T.; Abdul Karim, A.K.; Aziz, N.H.A.; Mokhtar, M.H.; et al. Endometrial Heparin-Binding Epidermal Growth Factor Gene Expression and Hormone Level Changes in Implantation Window of Obese Women with Polycystic Ovarian Syndrome. Biomedicines 2023, 11, 276. https://doi.org/10.3390/ biomedicines11020276en_US
dc.identifier.doi10.3390/biomedicines11020276
dc.identifier.epage9
dc.identifier.issn0970-2067
dc.identifier.issue276
dc.identifier.spage1
dc.identifier.urihttps://oarep.usim.edu.my/jspui/bitstream/123456789/19655/1/va9tq.pdf
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/7073
dc.identifier.volume11
dc.language.isoenen_US
dc.publisherMDPIen_US
dc.relation.ispartofBiomedicineen_US
dc.subjectgene expression; heparin-binding epidermal growth factor; hormonal assay; implantation window; obese; polycystic ovarian syndrome; progesterone therapyen_US
dc.titleEndometrial Heparin-binding Epidermal Growth Factor Gene Expression And Hormone Level Changes In Implantation\r\nWindow Of Obese Women With Polycystic Ovarian Syndromeen_US
dc.typeArticleen_US
dspace.entity.typePublication

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