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MMP-9: Biomarker for abdominal aneurysm

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dc.Chemicals/CASgelatinase B, 146480-36-6; Biomarkers; Matrix Metalloproteinase 9
dc.citedby2
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.affiliationsUniversiti Kebangsaan Malaysia (UKM)
dc.contributor.authorBin Affirul A.C.en_US
dc.contributor.authorAzim I.M.en_US
dc.contributor.authorHanafiah H.en_US
dc.contributor.authorNor Azmi K.en_US
dc.contributor.authorRozman Z.en_US
dc.date.accessioned2024-05-29T02:01:49Z
dc.date.available2024-05-29T02:01:49Z
dc.date.issued2014
dc.description.abstractPrior studies have shown the correlation between MMP-9 concentration levels with AAA raising the probability of its usage as a biomarker in AAA disease. However, results of previous studies have been conflicting. The purpose of this study is to identify the correlation between MMP-9 concentration levels with AAA disease and further define the utility as a biomarker for our center population. Materials and Methods: This is prospective controlled trial. Peripheral venous blood sample is obtained from 20 patients with AAA and 36 normal control subjects. MMP-9 concentration levels were determined by an enzyme-linked immunosorbent assay and compared with subjects abdominal ultrasonography or computed tomography of abdomen. Results: Mean (�SE) MMP-9 was 23.94 � 0.60 ng/mL in normal control subjects and 21.39 � 1.03 ng/mL in patients with AAAs (p ?0.05 versus normal control subjects). MMP-9 correlate significantly with AAA (p=0.004). There was no correlation of MMP-9 levels with age, gender, or other risk factors. The cutoff point is 12.54 for aorta size <3.0cm. The sensitivity and specificity of MMP-9 were 60% and 64% respectively. Conclusions: MMP-9 levels correlate significantly with AAA with a cutoff point of 12.54. However, the utility of MMP-9 as a diagnostic test is limited due to low sensitivity and specificity. An elevated MMP-9 has limited use to predict the presence of AAA (positive predictive value: 60%) and a normal MMP-9 level was insufficient to determine the absence of AAA (negative predictive value: 36.1%). � Societ� Editrice Universo (SEU).en_US
dc.description.natureFinalen_US
dc.identifier.CODENCLTEA
dc.identifier.doi10.7417/CT.2013.1640
dc.identifier.epagee483
dc.identifier.issn99074
dc.identifier.issue6 SUPPL
dc.identifier.pmid24424226
dc.identifier.scopus2-s2.0-84896271978
dc.identifier.spagee479
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84896271978&doi=10.7417%2fCT.2013.1640&partnerID=40&md5=9953c157a23052496256e9c6dfcbf5f2
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/10186
dc.identifier.volume164
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherSocieta Editrice Universoen_US
dc.relation.ispartofClinica Terapeutica
dc.sourceScopus
dc.subjectabdominal aortic aneurysmen_US
dc.subjectBiomarkeren_US
dc.subjectMMP-9en_US
dc.titleMMP-9: Biomarker for abdominal aneurysmen_US
dc.title.alternativeClin. Ter.en_US
dc.typeArticleen_US
dspace.entity.typePublication

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