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Methanol leaf extract of Actinodaphne sesquipedalis (Lauraceae) enhances gastric defense against ethanol-induced ulcer in rats

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dc.contributor.authorHanita Omaren_US
dc.contributor.authorNoraziah Nordinen_US
dc.contributor.authorPouya Hassandarvishen_US
dc.contributor.authorMaryam Hajrezaieen_US
dc.contributor.authorAinnul Hamidah Syahadah Azizanen_US
dc.contributor.authorMehran Fadaeinasaben_US
dc.contributor.authorNazia Abdul Majiden_US
dc.contributor.authorMahmood Ameen Abdullaen_US
dc.contributor.authorNajihah Mohd Hashimen_US
dc.contributor.authorHapipah Mohd Alien_US
dc.date.accessioned2024-05-28T03:43:04Z
dc.date.available2024-05-28T03:43:04Z
dc.date.issued2017
dc.description.abstractActinodaphne sesquipedalis Hook. F. Var. Glabra (Kochummen), also known as "Medang payung" by the Malay people, belongs to the Lauraceae family. In this study, methanol leaf extract of A. sesquipedalis was investigated for their acute toxicity and gastroprotective effects to reduce ulcers in rat stomachs induced by ethanol. The rats were assigned to one of five groups: normal group (group 1), ulcer group (group 2), control positive drug group (group 3) and two experimental groups treated with 150 mg/kg (group 4) and 300 mg/kg (group 5) of leaf extract. The rats were sacrificed an hour after pretreatment with extracts, and their stomach homogenates and tissues were collected for further evaluation. Macroscopic and histological analyses showed that gastric ulcers in rats pretreated with the extract were significantly reduced to an extent that it allowed leukocytes penetration of the gastric walls compared with the ulcer group. In addition, an ulcer inhibition rate of >70% was detected in rats treated with both doses of A. sesquipedalis extract, showing a notable protection of gastric layer. Severe destruction of gastric mucosa was prevented with a high production of mucus and pH gastric contents in both omeprazole-treated and extract-treated groups. Meanwhile, an increase in glycoprotein uptake was observed in pretreated rats through accumulation of magenta color in Periodic Acid Schiff staining assay. Analysis of gastric homogenate from pretreated rats showed a reduction of malondialdehyde and elevation of nitric oxide, glutathione, prostaglandin E2, superoxide dismutase and protein concentration levels in comparison with group 2. Suppression of apoptosis in gastric tissues by upregulation of Hsp70 protein and downregulation of Bax protein was also observed in rats pretreated with extract. Consistent results of a reduction of gastric ulcer and the protection of gastric wall were obtained for rats pretreated with A. sesquipedalis extract, which showed its prominent gastroprotective potential in rats' stomach against ethanol-induced ulcer.en_US
dc.identifier.citationOmar H, Nordin N, Hassandarvish P, Hajrezaie M, Azizan AHS, Fadaeinasab M, Abdul Majid N, Abdulla MA, Mohd Hashim N, Mohd Ali H. Methanol leaf extract of Actinodaphne sesquipedalis (Lauraceae) enhances gastric defense against ethanol-induced ulcer in rats. Drug Des Devel Ther. 2017;11:1353-1365 https://doi.org/10.2147/DDDT.S120564en_US
dc.identifier.doihttps://doi.org/10.2147/DDDT.S120564
dc.identifier.epage1365
dc.identifier.issn1177-8881
dc.identifier.other2169-4
dc.identifier.spage1353
dc.identifier.urihttps://www.dovepress.com/methanol-leaf-extract-of-actinodaphne-sesquipedalis-lauraceae-enhances-peer-reviewed-fulltext-article-DDDT
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/4976
dc.identifier.volume11
dc.language.isoenen_US
dc.publisherDove Medical Press Ltd.en_US
dc.relation.ispartofDrug Design, Development and Therapyen_US
dc.subjectActinodaphne sesquipedalis;en_US
dc.subjectethanol; gastric ulcer;en_US
dc.subjectmechanism;en_US
dc.subjectmethanol extractsen_US
dc.titleMethanol leaf extract of Actinodaphne sesquipedalis (Lauraceae) enhances gastric defense against ethanol-induced ulcer in ratsen_US
dc.typeArticleen_US
dspace.entity.typePublication

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