Publication:
Increased Beat-to-beat Blood Pressure Variability is Associated With Impaired Cognitive Function

Simple item page
dc.contributor.authorNur Fazidah Asmujeen_US
dc.contributor.authorSumaiyah Maten_US
dc.contributor.authorChoon Hian Gohen_US
dc.contributor.authorPhyo Kyaw Myinten_US
dc.contributor.authorMaw Pin Tanen_US
dc.date.accessioned2024-05-28T04:45:42Z
dc.date.available2024-05-28T04:45:42Z
dc.date.issued2022
dc.date.submitted2022-12-22
dc.descriptionVolume 35, Issue 12, December 2022 (Pages:998–1005)en_US
dc.description.abstractBACKGROUND Emerging evidence has linked visit-to-visit, day-to-day and 24-h ABPM blood pressure variability (BPV) with cognitive impairment. Few studies have, however, considered beat-to-beat BPV. This study, therefore, evaluated the relationship between beat-to-beat BPV and cognitive function among community-dwellers aged 55 years and over. METHODS Data was obtained from the Malaysian Elders Longitudinal Research (MELoR) study, which employed random stratified sampling from three parliamentary constituencies within the Klang Valley. Beat-to-beat blood pressure (BP) was recorded using non-invasive BP monitoring (TaskforceTM, CNSystems). Low frequency (LF), high frequency (HF) and low-to-high frequency (LF:HF) ratio for BPV were derived using fast Fourier transformation. Cognition was evaluated using the Montreal Cognitive Assessment (MoCA) test, and categorized into normal aging, mild impairment and moderate-to-severe impairment. RESULTS Data from 1,140 individuals, mean age (SD) 68.48 (7.23) years, were included. Individuals with moderate-to-severe impairment had higher HF-BPV for systolic (SBP) and diastolic (DBP) blood pressure compared to individuals within the normal aging group [OR (95% CI) = 2.29 (1.62–3.24)] and [OR (95% CI) = 1.80 (1.32–2.45)], while HF-SBPV [OR (95% CI) = 1.41 (1.03–1.93)] but not HF-DBPV was significantly higher with mild impairment compared to normal aging after adjustments for potential confounders. Moderate-to-severe impairment was associated with significantly lower LF:HF-SBPV [OR (95% CI) = 0.29 (0.18–0.47)] and LF:HF-DBPV [OR (95% CI) = 0.49 (0.34–0.72)], while mild impairment was associated with significantly lower LF:HF-SBPV [OR (95% CI) = 0.52 (0.34–0.80)] but not LF:HF-DBPV [OR (95% CI) = 0.81 (0.57–1.17)], compared to normal aging with similar adjustments. CONCLUSION Higher HF-BPV, which indicates parasympathetic activation, and lower LF:HF-BPV, which addresses sympathovagal balance, were observed among individuals with moderate-to-severe cognitive impairment. Future studies should determine whether BPV could be a physiological marker or modifiable risk factor for cognitive decline.en_US
dc.identifier.citationNur Fazidah Asmuje, Mat, S., Choon Hian Goh, Phyo Kyaw Myint, & Maw Pin Tan. (2022). Increased Beat-to-Beat Blood Pressure Variability Is Associated With Impaired Cognitive Function. American Journal of Hypertension, 35(12), 998–1005. https://doi.org/10.1093/ajh/hpac107en_US
dc.identifier.doi10.1093/ajh/hpac107
dc.identifier.epage1005
dc.identifier.issn0895-7061
dc.identifier.issue12
dc.identifier.spage998
dc.identifier.urihttps://academic.oup.com/ajh/article-abstract/35/12/998/6717450?redirectedFrom=fulltext&login=true
dc.identifier.urihttps://www.scopus.com/record/display.uri?eid=2-s2.0-85143645208&origin=resultslist&sort=plf-f&src=s&sid=0a833cb6ec9621e495968cd3daaff0cc&sot=b&sdt=b&s=TITLE-ABS-KEY%28Increased+Beat-to-Beat+Blood+Pressure+Variability+Is+Associated+With+Impaired+Cognitive+Function%29&sl=111&sessionSearchId=0a833cb6ec9621e495968cd3daaff0cc&relpos=0
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/6143
dc.identifier.volume35
dc.language.isoen_USen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofAmerican Journal of Hypertensionen_US
dc.titleIncreased Beat-to-beat Blood Pressure Variability is Associated With Impaired Cognitive Functionen_US
dc.typeArticleen_US
dspace.entity.typePublication

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Increased Beat-to-Beat Blood Pressure Variability Is Associated With Impaired Cognitive Function.pdf
Size:
1.52 MB
Format:
Adobe Portable Document Format
Download

Collections

Other Publications