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DNA damage and protein oxidation associated with ageing correlate with cognitive dysfunction in a Malaysian population

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dc.contributor.authorSani, NFAen_US
dc.contributor.authorDamanhuri, MHAen_US
dc.contributor.authorHamzah, AIZAen_US
dc.contributor.authorAbu Bakar, ZHen_US
dc.contributor.authorTan, JKen_US
dc.contributor.authorAripin, KNNen_US
dc.contributor.authorRani, MDMen_US
dc.contributor.authorNoh, NAen_US
dc.contributor.authorShamaan, NAen_US
dc.contributor.authorRazali, Ren_US
dc.contributor.authorYusof, YAMen_US
dc.contributor.authorMazlan, Men_US
dc.contributor.authorMakpol, Sen_US
dc.contributor.authorNgah, WZWen_US
dc.date.accessioned2024-05-29T02:53:00Z
dc.date.available2024-05-29T02:53:00Z
dc.date.issued2018
dc.description.abstractAgeing is associated with increased oxidative stress accompanied by cognitive decline. The aim of this study was to evaluate oxidative stress biomarkers and their possible relationship with cognitive performances during ageing among the Malay population. Approximately 160 healthy Malay adults aged between 28 and 79 years were recruited around Selangor and Klang Valley. Cognitive function was assessed by Montreal Cognitive Assessment (MoCA), forward digit span (FDS), backward digit span (BDS), digit symbol, Rey Auditory Verbal Learning Test immediate recalled [RAVLT(I)] and delayed recalled [RAVLT(D)], and visual reproduction immediate recalled (VR-I) and delayed recalled (VR-II). DNA damage, plasma protein carbonyl and malondialdehyde (MDA) levels were also determined. Cognitive function test showed significant lower scores of MoCA, BDS, RAVLT(I), RAVLT(D), digit symbol, VR-I, and VR-II in the older age group (60 years old) compared with the 30-, 40-, and 50-year-old group. The extent of DNA damage was sequential with age: 60 > 50 > 40 > 30, whereas protein carbonyl was higher in 40-, 50-, and 60-year-old groups compared with the youngest group (30 years old). However, the MDA level was observed unchanged in all age groups. Approximately 21.88% of the participants had cognitive impairment. Multiple logistic regression analysis revealed that DNA damage and protein carbonyl levels are predictors for cognitive impairment in healthy Malays. In conclusion, cognitive decline occurred in healthy adult Malay population at an early age of 30 years old with corresponding higher DNA damage and protein oxidation.
dc.identifier.doi10.1080/10715762.2018.1506877
dc.identifier.epage1009
dc.identifier.isbn1029-2470
dc.identifier.issn1071-5762
dc.identifier.issue9
dc.identifier.scopusWOS:000453865900011
dc.identifier.spage1000
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/11355
dc.identifier.volume52
dc.languageEnglish
dc.language.isoen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofFree Radical Research
dc.sourceWeb Of Science (ISI)
dc.subjectOxidative stressen_US
dc.subjectcognitive impairmenten_US
dc.subjectageingen_US
dc.subjectcross-sectional studyen_US
dc.titleDNA damage and protein oxidation associated with ageing correlate with cognitive dysfunction in a Malaysian population
dc.typeArticleen_US
dspace.entity.typePublication

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