Publication:
Prenatal diagnosis of aneuploidies in amniotic fluid by multiple ligation-dependent probe amplification (MLPA) analysis

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dc.Chemicals/CASDNA Probes
dc.ManufacturersMRC
dc.TradenamesSALSA MLPA P095 Aneuploidy kit, MRC
dc.citedby2
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversiti Kebangsaan Malaysia (UKM) Medical Centre
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.authorHamidah N.H.en_US
dc.contributor.authorMunirah A.R.en_US
dc.contributor.authorHafiza A.en_US
dc.contributor.authorFARISAH A.R.en_US
dc.contributor.authorShuhaila A.en_US
dc.contributor.authorNorzilawati M.N.en_US
dc.contributor.authorJamil M.Y.en_US
dc.contributor.authorAinoon O.en_US
dc.date.accessioned2024-05-29T01:54:34Z
dc.date.available2024-05-29T01:54:34Z
dc.date.issued2014
dc.description.abstractPrenatal diagnosis is essential in the new era of diagnosis and management of genetic diseases in obstetrics. Multiple ligation-dependent probe amplification (MLPA) is a recent technique for prenatal diagnosis for the relative quantification of 40 different nucleic acid sequences in one single reaction. We had utilized the MLPA technique in detecting aneuploidies in amniotic fluid samples from 25 pregnant women from the Obstetrics and Gynaecology Department UKMMC, versus the quantitative fluorescent polymerase chain reaction (QF-PCR) method. Conclusive results were obtained in 18 cases and all were concordant with that of the QF-PCR. All four cases of trisomies were correctly identified including one case with maternal cell contamination. � 2014, Malaysian Society of Pathologists. All rights reserved.en_US
dc.description.natureFinalen_US
dc.identifier.epage168
dc.identifier.issn1268635
dc.identifier.issue3
dc.identifier.pmid25500514
dc.identifier.scopus2-s2.0-84918504716
dc.identifier.spage163
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84918504716&partnerID=40&md5=b4b630a19e2fdcaa87c8e815a31ec53c
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/9481
dc.identifier.volume36
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherMalaysian Society of Pathologistsen_US
dc.relation.ispartofMalaysian Journal of Pathology
dc.sourceScopus
dc.subjectAmniotic fluiden_US
dc.subjectDNAen_US
dc.subjectMultiple ligation probe amplification (MLPA)en_US
dc.subjectPCRen_US
dc.subjectPrenatal diagnosisen_US
dc.titlePrenatal diagnosis of aneuploidies in amniotic fluid by multiple ligation-dependent probe amplification (MLPA) analysisen_US
dc.title.alternativeMalays. J. Pathol.en_US
dc.typeArticleen_US
dspace.entity.typePublication

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