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Hoxa10 Dna Methylation Level In The Endometrium Women With Endometriosis: A Systematic Review

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dc.contributor.authorMarjanu Hikmah Binti Eliasen_US
dc.contributor.authorNurunnajah Lazimen_US
dc.contributor.authorZulazmi Bin Sutajien_US
dc.contributor.authorMohammad Azrai Abuen_US
dc.contributor.authorAbdul Kadir Abdul Karimen_US
dc.contributor.authorAzizah Ugusmanen_US
dc.contributor.authorSaiful Effendi Syafruddinen_US
dc.contributor.authorMohd Helmy Mokhtaren_US
dc.contributor.authorMohd Faizal Ahmaden_US
dc.date.accessioned2024-05-28T06:37:41Z
dc.date.available2024-05-28T06:37:41Z
dc.date.issued2023
dc.date.submitted2023-4-19
dc.descriptionVolume 12 Issue 3 Page (1-11)en_US
dc.description.abstractEndometriosis is an inflammatory chronic systemic disease resulting in pelvic pain and infertility. However, despite a high prevalence of endometriosis, disease identification is still insufficient, and a high percentage of misdiagnosing was observed. Hence, a comprehensive study needs to be done to improve our understanding of the pathogenesis of endometriosis. Aberrant hypermethylation of HOXA10 has been reported to play a role in endometriosis. Thus, a comprehensive literature search was conducted to identify the DNA methylation level of HOXA10 among endometriosis patients across populations. The literature search was done using PubMed, Scopus, EBSCOhost, and Science Direct applying (HOXA10 OR “homeobox A10” OR “HOXA-10” OR HOX1) AND (“DNA methylation” OR methylation) AND (endometriosis OR endometrioma) as keywords. From 491 retrieved studies, five original articles investigating the DNA methylation level of HOXA10 from endometrium tissues among endometriosis women were included. All five included studies were classified as high-quality studies. High HOXA10 DNA methylation level was observed in the endometrium tissue of women with endometriosis in all the included studies. The secretory phase was identified as the best sampling time for HOXA10 DNA methylation study in endometriosis, and the most studied DNA methylation site is the promoter region of the HOXA10. However, more studies are needed to expose the HOXA10 mechanism in the pathogenesis of endometriosis.en_US
dc.identifier.citationElias, M.H.; Lazim, N.; Sutaji, Z.; Abu, M.A.; Abdul Karim, A.K.; Ugusman, A.; Syafruddin, S.E.; Mokhtar, M.H.; Ahmad, M.F. HOXA10 DNA Methylation Level in the Endometrium Women with Endometriosis: A Systematic Review. Biology 2023, 12, 474. https:// doi.org/10.3390/biology1203047en_US
dc.identifier.doi10.3390/biology12030474
dc.identifier.epage11
dc.identifier.issn2079-7737
dc.identifier.issue474
dc.identifier.spage1
dc.identifier.urihttps://www.mdpi.com/2079-7737/12/3/474
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/7402
dc.identifier.volume12
dc.language.isoen_USen_US
dc.publisherMDPIen_US
dc.relation.ispartofBiologyen_US
dc.subjectDNA methylation; endometriosis; endometrium; eutopic endometrium; ectopic endometrium; secretory phase; proliferative phaseen_US
dc.titleHoxa10 Dna Methylation Level In The Endometrium Women With Endometriosis: A Systematic Reviewen_US
dc.typeArticleen_US
dspace.entity.typePublication

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