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The toxicity of angiotensin converting enzyme inhibitors to larvae of the disease vectors Aedes aegypti and Anopheles gambiae

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dc.Chemicals/CAScaptopril, 62571-86-2; dipeptidyl carboxypeptidase, 9015-82-1; fosinopril, 88889-14-9, 98048-97-6; fosinoprilat, 95399-71-6; Angiotensin-Converting Enzyme Inhibitors; Captopril; Fosinopril; fosinoprilat; Insecticides; Peptidyl-Dipeptidase A
dc.citedby1
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.affiliationsUniversity of Leeds
dc.contributor.affiliationsLiverpool School of Tropical Medicine
dc.contributor.affiliationsUniversiti Kebangsaan Malaysia (UKM)
dc.contributor.affiliationsUniversity of Bath
dc.contributor.authorAbu Hasan Z.-I.en_US
dc.contributor.authorWilliams H.en_US
dc.contributor.authorIsmail N.M.en_US
dc.contributor.authorOthman H.en_US
dc.contributor.authorCozier G.E.en_US
dc.contributor.authorAcharya K.R.en_US
dc.contributor.authorIsaac E.R.en_US
dc.date.accessioned2024-05-28T08:26:22Z
dc.date.available2024-05-28T08:26:22Z
dc.date.issued2017
dc.description.abstractThe control of mosquitoes is threatened by the appearance of insecticide resistance and therefore new control chemicals are urgently required. Here we show that inhibitors of mosquito peptidyl dipeptidase, a peptidase related to mammalian angiotensin-converting enzyme (ACE), are insecticidal to larvae of the mosquitoes, Aedes aegypti and Anopheles gambiae. ACE inhibitors (captopril, fosinopril and fosinoprilat) and two peptides (trypsin-modulating oostatic factor/TMOF and a bradykinin-potentiating peptide, BPP-12b) were all inhibitors of the larval ACE activity of both mosquitoes. Two inhibitors, captopril and fosinopril (a pro-drug ester of fosinoprilat), were tested for larvicidal activity. Within 24 h captopril had killed >90% of the early instars of both species with 3 rd instars showing greater resistance. Mortality was also high within 24 h of exposure of 1 st, 2 nd and 3 rd instars of An. gambiae to fosinopril. Fosinopril was also toxic to Ae. aegypti larvae, although the 1 st instars appeared to be less susceptible to this pro-drug even after 72 h exposure. Homology models of the larval An. gambiae ACE proteins (AnoACE2 and AnoACE3) reveal structural differences compared to human ACE, suggesting that structure-based drug design offers a fruitful approach to the development of selective inhibitors of mosquito ACE enzymes as novel larvicides. � The Author(s) 2017.en_US
dc.description.natureFinalen_US
dc.identifier.ArtNo45409
dc.identifier.doi10.1038/srep45409
dc.identifier.issn20452322
dc.identifier.pmid28345667
dc.identifier.scopus2-s2.0-85016285336
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85016285336&doi=10.1038%2fsrep45409&partnerID=40&md5=779b027b8bcfa7f51937025b54af9b7b
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/8727
dc.identifier.volume7
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.ispartofOpen Accessen_US
dc.relation.ispartofScientific Reports
dc.sourceScopus
dc.titleThe toxicity of angiotensin converting enzyme inhibitors to larvae of the disease vectors Aedes aegypti and Anopheles gambiaeen_US
dc.title.alternativeSci. Rep.en_US
dc.typeArticleen_US
dspace.entity.typePublication

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