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Practical approach in hepatitis B e antigen-negative individuals to identify treatment candidates

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dc.Chemicals/CASalanine aminotransferase, 9000-86-6, 9014-30-6; Antiviral Agents; Biological Markers; Hepatitis B e Antigens
dc.citedby2
dc.contributor.affiliationsFaculty of Medicine and Health Sciences
dc.contributor.affiliationsUniversiti Sains Islam Malaysia (USIM)
dc.contributor.affiliationsHospital Selayang
dc.contributor.affiliationsUniversity of Malaya (UM)
dc.contributor.authorAzmi A.N.en_US
dc.contributor.authorTan S.-S.en_US
dc.contributor.authorMohamed R.en_US
dc.date.accessioned2024-05-29T01:56:41Z
dc.date.available2024-05-29T01:56:41Z
dc.date.issued2014
dc.description.abstractThe natural history of chronic hepatitis B is characterized by different phases of infection, and patients may evolve from one phase to another or may revert to a previous phase. The hepatitis B e antigen (HBeAg)-negative form is the predominant infection worldwide, which consists of individuals with a range of viral replication and liver disease severity. Although alanine transaminase (ALT) remains the most accessible test available to clinicians for monitoring the liver disease status, further evaluations are required for some patients to assess if treatment is warranted. Guidance from practice guidelines together with thorough investigations and classifications of patients ensure recognition of who needs which level of care. This article aims to assist physicians in the assessment of HBeAg-negative individuals using liver biopsy or non-invasive tools such as hepatitis B s antigen quantification and transient elastography in addition to ALT and hepatitis B virus DNA, to identify who will remain stable, who will reactivate or at risk of disease progression hence will benefit from timely initiation of anti-viral therapy. � 2014 Baishideng Publishing Group Inc. All rights reserved.en_US
dc.description.natureFinalen_US
dc.identifier.CODENWJGAF
dc.identifier.doi10.3748/wjg.v20.i34.12045
dc.identifier.epage12055
dc.identifier.issn10079327
dc.identifier.issue34
dc.identifier.pmid25232242
dc.identifier.scopus2-s2.0-84909636014
dc.identifier.spage12045
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84909636014&doi=10.3748%2fwjg.v20.i34.12045&partnerID=40&md5=b4c1731266d6ff884cdf10426a3ef7c6
dc.identifier.urihttps://oarep.usim.edu.my/handle/123456789/9861
dc.identifier.volume20
dc.languageEnglish
dc.language.isoen_USen_US
dc.publisherWJG Pressen_US
dc.relation.ispartofOpen Accessen_US
dc.relation.ispartofWorld Journal of Gastroenterology
dc.sourceScopus
dc.subjectChronic hepatitis Ben_US
dc.subjectHepatitis B e antigen-negativeen_US
dc.subjectHepatitis B s antigen levelen_US
dc.subjectNucleos(t)ides analoguesen_US
dc.subjectPegylated interferonen_US
dc.subjectTreatment candidatesen_US
dc.titlePractical approach in hepatitis B e antigen-negative individuals to identify treatment candidatesen_US
dc.title.alternativeWorld J. Gastroenterol.en_US
dc.typeArticleen_US
dspace.entity.typePublication

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